Arnold Julia T
LCI-Endocrine Section, National Center for Complementary and Alternative Medicine (NCCAM), National Institutes of Health (NIH), Building 10/2B47 MSC 1547, 9000 Rockville Pike, Bethesda, MD 20892-1547, USA.
Mol Cell Endocrinol. 2009 Mar 25;301(1-2):83-8. doi: 10.1016/j.mce.2008.10.019. Epub 2008 Nov 1.
Dehydroepiandrosterone (DHEA) is commonly used in the USA as a nutritional supplement for antiaging, metabolic support or other uses. Investigations into understanding the effects of DHEA on human prostate cancer progression have posed more questions than answers and highlight the importance of communications between stromal and epithelial tuoitiuot elements within the prostate that contribute to the regulation of DHEA metabolism. Intracrine metabolism of DHEA to androgens (A) and/or estrogens (E) may occur in one cell compartment (stromal) which may release paracrine hormones or growth/inhibitory factors to the epithelial cells. Alternatively no metabolism of DHEA may occur, resulting in no harmful consequences of high levels of DHEA in prostate tissues. We herein review the tissue components involved and interactions with the prohormone, DHEA and/or resulting metabolites, including dihydrotestosterone (DHT) or 17beta-estradiol (E(2)) in an in vitro model of endocrine-immune-paracrine interactions within the prostate. This work raises questions and hypotheses concerning the role of DHEA in prostate in normal tissues, vs. preneoplastic tissues.
脱氢表雄酮（DHEA）在美国通常用作抗衰老、代谢支持或其他用途的营养补充剂。关于DHEA对人类前列腺癌进展影响的研究提出的问题比答案更多，并突出了前列腺内基质和上皮成分之间通讯的重要性，这些成分有助于调节DHEA代谢。DHEA在内分泌代谢为雄激素（A）和/或雌激素（E）的过程可能发生在一个细胞区室（基质）中，该区室可能会向上皮细胞释放旁分泌激素或生长/抑制因子。或者，DHEA可能不会发生代谢，从而不会导致前列腺组织中高水平的DHEA产生有害后果。我们在此回顾了前列腺内分泌-免疫-旁分泌相互作用体外模型中涉及的组织成分以及与前体激素DHEA和/或产生的代谢物（包括双氢睾酮（DHT）或17β-雌二醇（E₂））的相互作用。这项工作提出了关于DHEA在正常组织与癌前组织中前列腺的作用的问题和假设。
