Park Jin Young, Mitrou Panagiota N, Luben Robert, Khaw Kay-Tee, Bingham Sheila A
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Eur J Cancer. 2009 Jan;45(1):139-45. doi: 10.1016/j.ejca.2008.10.002. Epub 2008 Nov 14.
Bowel habit has been associated with colorectal carcinogenesis; however, findings from epidemiologic studies have been limited and inconsistent. The aim of this study was to explore the association between bowel habit and colorectal cancer (CRC) risk in the UK-Norfolk arm of the European Prospective Investigation Into Cancer and Nutrition (EPIC-Norfolk), a study of 25,663 men and women aged 45-79 years at entry. Having loose stools compared to soft stools was associated with an approximately 3-fold increased risk, and the association remained significant when lifestyle factors and bowel habit variables were included as covariates in the model (odds ratio (OR), 2.80; 95% confidence interval (CI), 1.41-5.56). The significantly elevated risk estimate persisted when we further excluded CRC cases within 3 years of follow-up. Frequency of bowel movement, stool quantity, feeling discomfort and laxative use was not overall associated with CRC risk. These findings suggest that having loose stools may be an indicator of colorectal cancer risk.
排便习惯与结直肠癌发生有关；然而，流行病学研究结果有限且不一致。本研究旨在探讨欧洲癌症与营养前瞻性调查（EPIC - 诺福克）英国 - 诺福克队列中排便习惯与结直肠癌（CRC）风险之间的关联，该队列研究纳入了25663名年龄在45 - 79岁的男性和女性。与软便相比，腹泻与风险增加约3倍相关，当将生活方式因素和排便习惯变量作为协变量纳入模型时，这种关联仍然显著（比值比（OR）为2.80；95%置信区间（CI）为1.41 - 5.56）。当我们进一步排除随访3年内的CRC病例时，风险估计值仍显著升高。排便频率、粪便量、不适感和泻药使用总体上与CRC风险无关。这些发现表明腹泻可能是结直肠癌风险的一个指标。
