Tashiro Naotaka, Budhathoki Sanjeev, Ohnaka Keizo, Toyomura Kengo, Kono Suminori, Ueki Takashi, Tanaka Masao, Kakeji Yoshihiro, Maehara Yoshihiko, Okamura Takeshi, Ikejiri Koji, Futami Kitaroh, Maekawa Takafumi, Yasunami Yohichi, Takenaka Kenji, Ichimiya Hitoshi, Terasaka Reiji
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Asian Pac J Cancer Prev. 2011;12(8):2025-30.
Constipation has been suspected to be linked to colorectal cancer risk, but epidemiological evidence is inconclusive. We described the prevalence of constipation and related lifestyle factors in a community and examined the relation of constipation and other bowel habits to colorectal cancer risk. The prevalence study was based on 833 community controls in the Fukuoka Colorectal Cancer Study, and 212 cases of Dukes' stage A were used in a study on bowel habits and colorectal cancer risk. Bowel habits were assessed by in-person interview. Odds ratio (OR) and 95% confidence interval (CI) of colorectal cancer were estimated with adjustment for dietary and nondietary factors. Constipation was reported by 10.3% of men and 27.7% of women. Individuals with less frequent bowel movements had a lower intake of total energy and were physically less active. The multivariate-adjusted OR (95% CI) of colorectal cancer were 1.51 (1.02-2.25) for self-reported constipation, 1.60 (1.05-2.44) for functional constipation, and 1.24 (0.81-1.90) for infrequent bowel movements (<1 stool/day). Self-reported constipation was fairly common in Japanese adults. Constipation was associated with a moderately increased risk of colorectal cancer.
便秘一直被怀疑与结直肠癌风险有关，但流行病学证据尚无定论。我们描述了一个社区中便秘及相关生活方式因素的患病率，并研究了便秘和其他排便习惯与结直肠癌风险之间的关系。患病率研究基于福冈结直肠癌研究中的833名社区对照者，在一项关于排便习惯和结直肠癌风险的研究中使用了212例杜克A期病例。排便习惯通过面对面访谈进行评估。在对饮食和非饮食因素进行调整后，估计了结直肠癌的比值比（OR）和95%置信区间（CI）。报告有便秘的男性占10.3%，女性占27.7%。排便频率较低的个体总能量摄入量较低，身体活动较少。自我报告便秘的结直肠癌多变量调整OR（95%CI）为1.51（1.02 - 2.25），功能性便秘为1.60（1.05 - 2.44），排便不频繁（每天<1次大便）为1.24（0.81 - 1.90）。自我报告的便秘在日本成年人中相当常见。便秘与结直肠癌风险适度增加有关。
