Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Cancer Causes Control. 2013 May;24(5):1015-24. doi: 10.1007/s10552-013-0176-2. Epub 2013 Mar 2.
The associations between bowel movement frequency, laxative use, and colorectal cancer incidence remain uncertain. No published studies have accounted for potential latency between these factors and colorectal cancer onset.
We prospectively examined these associations among 88,173 women in the Nurses' Health Study (NHS, 1982-2010) and 23,722 men in the Health Professionals Follow-up Study (HPFS, 2000-2010). Cox proportional hazards regression models were used to estimate multivariable hazard ratios (HRs, 95 % CIs). We conducted time lagged analyses to evaluate the potential latency in the NHS.
We documented 2,012 incident colorectal cancer cases. The HRs (95 % CIs) for infrequent bowel movement relative to daily were 0.86 (95 % CI 0.71-1.04) in women and 0.81 (95 % CI 0.48-1.37) in men. The HRs for weekly to daily relative to never laxative use were 0.98 (95 % CI 0.81-1.20) in women and 1.41 (95 % CI 0.96-2.06) in men. In women, the HRs for every 3 days or less bowel movement relative to daily were 0.87 (95 % CI 0.59-1.27) for colorectal cancers that developed within 10 years of assessment, 1.03 (95 % CI 0.85-1.26) for 11-18 years after assessment, and 0.73 (95 % CI 0.54-1.01) for 19-28 years after assessment. The corresponding HRs for weekly to daily relative to never laxative use were 0.93 (95 % CI 0.63-1.37), 1.03 (95 % CI 0.74-1.44), and 0.98 (95 % CI 0.71-1.35), respectively.
Bowel movement frequency and laxative use appear not to be associated with colorectal cancer risk in this study.
排便频率、泻药使用与结直肠癌发病率之间的关联仍不确定。目前尚无研究考虑这些因素与结直肠癌发病之间潜在的潜伏期。
我们前瞻性地研究了护士健康研究（NHS，1982-2010 年）中的 88173 名女性和健康专业人员随访研究（HPFS，2000-2010 年）中的 23722 名男性中这些关联。采用 Cox 比例风险回归模型估计多变量风险比（HR，95%CI）。我们进行了时间滞后分析，以评估 NHS 中的潜在潜伏期。
我们记录了 2012 例结直肠癌病例。与每日排便相比，排便不频繁的 HR（95%CI）分别为女性 0.86（95%CI 0.71-1.04）和男性 0.81（95%CI 0.48-1.37）。与从不使用泻药相比，每周至每日相对 HR 分别为女性 0.98（95%CI 0.81-1.20）和男性 1.41（95%CI 0.96-2.06）。在女性中，与每日排便相比，每 3 天或更少排便的 HR 分别为 10 年内评估的结直肠癌为 0.87（95%CI 0.59-1.27），11-18 年后评估的为 1.03（95%CI 0.85-1.26），19-28 年后评估的为 0.73（95%CI 0.54-1.01）。与从不使用泻药相比，每周至每日相对 HR 分别为 0.93（95%CI 0.63-1.37）、1.03（95%CI 0.74-1.44）和 0.98（95%CI 0.71-1.35）。
在这项研究中，排便频率和泻药使用似乎与结直肠癌风险无关。
