Department of Pediatrics, Rheumatology Section, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, USA.
Pediatr Rheumatol Online J. 2008 Nov 17;6:19. doi: 10.1186/1546-0096-6-19.
One of the least-appreciated advances in pediatric rheumatology over the past 25 years has been the delineation of the many ways in which children with rheumatic disease differ from adults with the same illnesses. Furthermore, we are now learning that paradigms that are useful in evaluating adults with musculoskeletal complaints have limited utility in children. Nowhere is that more true than in the use of commonly used laboratory tests, particularly antinuclear antibody (ANA) and rheumatoid factor (RF) assays. This short review will provide the practitioner with the evidence base that supports a more limited use of ANA and RF testing in children.
在过去的 25 年中,儿科风湿病学最不被重视的进展之一是阐明了患有风湿病的儿童与患有相同疾病的成年人在许多方面的不同之处。此外,我们现在还了解到,在评估患有肌肉骨骼投诉的成年人时有用的范例在儿童中用途有限。在常用实验室检测的使用方面,尤其是抗核抗体(ANA)和类风湿因子(RF)检测,更是如此。这篇简短的综述将为临床医生提供支持在儿童中更有限地使用 ANA 和 RF 检测的证据基础。