Yang James J, Burchard Esteban G, Choudhry Shweta, Johnson Christine C, Ownby Dennis R, Favro David, Chen Justin, Akana Matthew, Ha Connie, Kwok Pui-Yan, Krajenta Richard, Havstad Suzanne L, Joseph Christine L, Seibold Max A, Shriver Mark D, Williams L Keoki
Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Mich.
Department of Medicine, University of California San Francisco, San Francisco, Calif; Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, Calif.
J Allergy Clin Immunol. 2008 Oct;122(4):820-827.e9. doi: 10.1016/j.jaci.2008.07.044.
Many allergic conditions occur more frequently in African American patients when compared with white patients; however, it is not known whether this represents genetic predisposition or disparate environmental exposures.
We sought to assess the relationship of self-reported race and genetic ancestry to allergic sensitization.
We included 601 women enrolled in a population-based cohort study whose self-reported race was African American or white. Genetic ancestry was estimated by using markers that differentiate West African and European ancestry. We assessed the relationship between allergic sensitization (defined as > or =1 allergen-specific IgE results) and both self-reported race and genetic ancestry. Regression models adjusted for sociodemographic variables, environmental exposures, and location of residence.
The average proportion of West African ancestry in African American participants was 0.69, whereas the mean proportion of European ancestry in white participants was 0.79. Self-reported African American race was associated with allergic sensitization when compared with those who reported being white (adjusted odds ratio, 2.19; 95% CI, 1.22-3.93), even after adjusting for other variables. Genetic ancestry was not significantly associated with allergic sensitization after accounting for location of residence (adjusted odds ratio, 2.09 for urban vs suburban residence; 95% CI, 1.32-3.31).
Self-reported race and location of residence appeared to be more important predictors of allergic sensitization when compared with genetic ancestry, suggesting that the disparity in allergic sensitization by race might be primarily a result of environmental factors rather than genetic differences.
与白人患者相比，许多过敏病症在非裔美国患者中更为常见；然而，尚不清楚这是代表遗传易感性还是不同的环境暴露。
我们试图评估自我报告的种族和遗传血统与过敏致敏之间的关系。
我们纳入了601名参与基于人群的队列研究的女性，她们自我报告的种族为非裔美国人或白人。通过使用区分西非和欧洲血统的标记来估计遗传血统。我们评估了过敏致敏（定义为≥1种过敏原特异性IgE结果）与自我报告的种族和遗传血统之间的关系。回归模型对社会人口统计学变量、环境暴露和居住地点进行了调整。
非裔美国参与者中西非血统的平均比例为0.69，而白人参与者中欧洲血统的平均比例为0.79。与报告为白人的人相比，自我报告为非裔美国人的种族与过敏致敏相关（调整后的优势比为2.19；95%置信区间为1.22 - 3.93），即使在对其他变量进行调整之后。在考虑居住地点后，遗传血统与过敏致敏无显著关联（城市与郊区居住的调整后优势比为2.09；95%置信区间为1.32 - 3.31）。
与遗传血统相比，自我报告的种族和居住地点似乎是过敏致敏更重要的预测因素，这表明种族间过敏致敏的差异可能主要是环境因素而非遗传差异导致的。
