aDivision of Allergy and Immunology, Children’s Memorial Hospital, Chicago, Illinois 60614, USA.
Pediatrics. 2011 Oct;128(4):e821-9. doi: 10.1542/peds.2011-0691. Epub 2011 Sep 2.
We examined whether the risk of food-allergen sensitization varied according to self-identified race or genetic ancestry.
We studied 1104 children (mean age: 2.7 years) from an urban multiethnic birth cohort. Food sensitization was defined as specific immunoglobulin E (sIgE) levels of ≥ 0.35 kilo-units of allergen (kUA)/L for any of 8 common food allergens. Multivariate logistic regression analyses were used to evaluate the associations of self-identified race and genetic ancestry with food sensitization. Analyses also examined associations with numbers of food sensitizations (0, 1 or 2, and ≥ 3 foods) and with logarithmically transformed allergen sIgE levels.
In this predominantly minority cohort (60.9% black and 22.5% Hispanic), 35.5% of subjects exhibited food sensitizations. In multivariate models, both self-reported black race (odds ratio [OR]: 2.34 [95% confidence interval [CI]: 1.24-4.44]) and African ancestry (in 10% increments; OR: 1.07 [95% CI: 1.02-1.14]) were associated with food sensitization. Self-reported black race (OR: 3.76 [95% CI: 1.09-12.97]) and African ancestry (OR: 1.19 [95% CI: 1.07-1.32]) were associated with a high number (≥ 3) of food sensitizations. African ancestry was associated with increased odds of peanut sIgE levels of ≥ 5 kUA/L (OR: 1.25 [95% CI: 1.01-1.52]). Similar ancestry associations were seen for egg sIgE levels of ≥ 2 kUA/L (OR: 1.13 [95% CI: 1.01-1.27]) and milk sIgE levels of ≥ 5 kUA/L (OR: 1.24 [95% CI: 0.94-1.63]), although findings were not significant for milk.
Black children were more likely to be sensitized to food allergens and were sensitized to more foods. African ancestry was associated with peanut sensitization.
我们研究了食物过敏敏化的风险是否因自我认定的种族或遗传血统而异。
我们研究了一个城市多民族出生队列中的 1104 名儿童（平均年龄：2.7 岁）。食物过敏被定义为对 8 种常见食物过敏原中的任何一种的特异性免疫球蛋白 E（sIgE）水平≥0.35 千单位的过敏原（kUA）/L。多变量逻辑回归分析用于评估自我认定的种族和遗传血统与食物过敏的关系。分析还检查了与食物过敏数量（0、1 或 2 和≥3 种食物）以及对数转换的过敏原 sIgE 水平的关联。
在这个主要是少数族裔的队列中（60.9%为黑人，22.5%为西班牙裔），35.5%的受试者表现出食物过敏。在多变量模型中，自我报告的黑种人种族（比值比[OR]：2.34[95%置信区间[CI]：1.24-4.44]）和非洲血统（每增加 10%；OR：1.07[95%CI：1.02-1.14]）均与食物过敏有关。自我报告的黑种人种族（OR：3.76[95%CI：1.09-12.97]）和非洲血统（OR：1.19[95%CI：1.07-1.32]）与多种食物过敏（≥3 种）相关。非洲血统与花生 sIgE 水平≥5 kUA/L（OR：1.25[95%CI：1.01-1.52]）的几率增加有关。鸡蛋 sIgE 水平≥2 kUA/L（OR：1.13[95%CI：1.01-1.27]）和牛奶 sIgE 水平≥5 kUA/L（OR：1.24[95%CI：0.94-1.63]）也观察到类似的遗传关联，尽管牛奶的结果不显著。
黑人儿童更容易对食物过敏原过敏，并且对更多的食物过敏。非洲血统与花生过敏有关。
