Theisen M M, Maas M, Hartlage M A Grosse, Ploner F, Niehues S M, Van Aken H K, Weber T P, Unger J K
Department of Anaesthesiology and Intensive Care, Münster University Hospital, Albert-Schweitzer-Strasse 33, D-48149 Münster, Germany.
Lab Anim. 2009 Jan;43(1):96-101. doi: 10.1258/la.2008.008044. Epub 2008 Nov 17.
The aim of this study was to find the fastest, easiest and safest method of achieving orotracheal intubation for general anaesthesia in laboratory pigs. Twenty-one Yorkshire x Landrace crossbreed male castrated pigs (32.9 +/- 4.8 kg) were investigated. Dorsal and ventral recumbency are the alternatives most frequently described for animal positioning during intubation procedures. Based on standardized induction of general anaesthesia using pentobarbital and remifentanil, the dorsoventral and ventrodorsal positions were compared with regard to the time needed, changes in oxygenation and circulatory response. Positioning was found to be crucial for fast orotracheal intubation. The time required for safe intubation is significantly shorter with the ventrodorsal position (17.3 s) in comparison with the dorsoventral position (58.4 s; P < 0.001). Hypoxia did not occur in either group. A significant drop in systolic blood pressure was observed in both groups. Diastolic and mean arterial pressures were not influenced by intubation. A significant increase in heart rate was observed in pigs intubated in ventral recumbency, but not after intubation in the dorsal position. Preoxygenation before intubation is vitally important for preventing hypoxia. With regard to clinical practice, the haemodynamic changes observed in this investigation do not appear to be relevant, as the mean arterial pressure was not altered and heart rates only increased moderately. It may be concluded that the ventrodorsal position can be recommended for orotracheal intubation in pigs as the first choice for providing a smooth and fast airway.
本研究的目的是找到在实验猪中进行全身麻醉时实现口气管插管的最快、最简单且最安全的方法。对21头约克夏×长白杂交雄性去势猪(体重32.9±4.8千克)进行了研究。仰卧位和俯卧位是插管过程中动物体位最常描述的两种选择。基于使用戊巴比妥和瑞芬太尼进行全身麻醉的标准化诱导,比较了腹背位和背腹位在所需时间、氧合变化和循环反应方面的差异。发现体位对于快速口气管插管至关重要。与背腹位(58.4秒;P<0.001)相比,腹背位安全插管所需时间显著更短(17.3秒)。两组均未发生缺氧情况。两组均观察到收缩压显著下降。舒张压和平均动脉压不受插管影响。腹卧位插管的猪心率显著增加,但背卧位插管后未出现这种情况。插管前预充氧对于预防缺氧至关重要。就临床实践而言,本研究中观察到的血流动力学变化似乎无关紧要,因为平均动脉压未改变且心率仅适度增加。可以得出结论,腹背位可作为猪口气管插管的首选推荐体位,以提供顺畅且快速的气道。