Larsson Susanna C, Akesson Agneta, Wolk Alicja
Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Am J Epidemiol. 2009 Feb 1;169(3):376-81. doi: 10.1093/aje/kwn319. Epub 2008 Nov 17.
The association between dietary acrylamide intake and the incidence of invasive breast cancer was examined among 61,433 Swedish women who were cancer free and completed a food frequency questionnaire in 1987-1990 and again in 1997. During a mean follow-up of 17.4 years, a total of 2,952 incident cases of breast cancer were diagnosed in the cohort. In multivariate analyses controlling for breast cancer risk factors, no statistically significant association was observed between long-term acrylamide intake (assessed at baseline and in 1997) and the risk of breast cancer, overall or by estrogen receptor (ER) and progesterone receptor (PR) status. The multivariate rate ratios comparing extreme quartiles of acrylamide intake were 0.91 (95% confidence interval (CI): 0.80, 1.02) for overall breast cancer, 0.89 (95% CI: 0.74, 1.08) for ER+PR+ tumors, 1.17 (95% CI: 0.84, 1.64) for ER+PR- tumors, and 0.91 (95% CI: 0.61, 1.38) for ER-PR- tumors. The association between acrylamide intake and breast cancer risk did not differ by smoking status. These findings for Swedish women do not support the hypothesis that dietary acrylamide is positively associated with risk of breast cancer, at least not within the ranges of acrylamide consumed by this population.
在61433名无癌症的瑞典女性中，研究了膳食丙烯酰胺摄入量与浸润性乳腺癌发病率之间的关联。这些女性在1987 - 1990年完成了一份食物频率问卷，并于1997年再次填写。在平均17.4年的随访期间，该队列中共诊断出2952例乳腺癌新发病例。在对乳腺癌风险因素进行多变量分析时，未观察到长期丙烯酰胺摄入量（在基线和1997年评估）与乳腺癌风险之间存在统计学上的显著关联，无论是总体情况还是按雌激素受体（ER）和孕激素受体（PR）状态分析。比较丙烯酰胺摄入量极端四分位数的多变量率比，总体乳腺癌为0.91（95%置信区间（CI）：0.80, 1.02），ER + PR +肿瘤为0.89（95% CI：0.74, 1.08），ER + PR -肿瘤为1.17（95% CI：0.84, 1.64），ER - PR -肿瘤为0.91（95% CI：0.61, 1.38）。丙烯酰胺摄入量与乳腺癌风险之间的关联在吸烟状况方面无差异。这些针对瑞典女性的研究结果不支持膳食丙烯酰胺与乳腺癌风险呈正相关的假设，至少在该人群所摄入的丙烯酰胺范围内不支持。
