膳食丙烯酰胺摄入与芬兰男性吸烟者癌症风险的关系。
Dietary acrylamide intake and the risk of cancer among Finnish male smokers.
机构信息
Finnish Food Safety Authority, Risk Assessment Unit, Mustialankatu 3, FI-00790 Helsinki, Finland.
出版信息
Cancer Causes Control. 2010 Dec;21(12):2223-9. doi: 10.1007/s10552-010-9642-2. Epub 2010 Sep 22.
OBJECTIVE
To assess the association between dietary acrylamide intake and the risk of cancer among male smokers.
METHODS
The study consisted of 27,111 male smokers, aged 50-69 years, without history of cancer. They were participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study in Finland. The men completed a validated dietary questionnaire and a questionnaire on general background characteristics (including smoking habits) at baseline. Incident cases of cancer were identified through the national Finnish Cancer Registry.
RESULTS
During an average 10.2 year follow-up, 1,703 lung cancers, 799 prostate cancers, 365 urothelial cancers, 316 colorectal cancers, 224 stomach cancers, 192 pancreatic cancers, 184 renal cell cancers, and 175 lymphomas were diagnosed. Dietary acrylamide intake was positively associated with the risk of lung cancer; relative risk (RR) in the highest versus the lowest quintile in the multivariable-adjusted model was 1.18 ((95% confidence interval (CI) 1.01-1.38, p for trend 0.11). Other cancers were not associated with acrylamide intake.
CONCLUSIONS
High acrylamide intake is associated with increased risk of lung cancer but not with other cancers in male smokers.
目的
评估膳食丙烯酰胺摄入与男性吸烟者癌症风险之间的关联。
方法
该研究纳入了 27111 名年龄在 50-69 岁、无癌症病史的男性吸烟者。他们是芬兰 Alpha-生育酚、β-胡萝卜素癌症预防（ATBC）研究的参与者。男性在基线时完成了一份经过验证的饮食问卷和一份关于一般背景特征（包括吸烟习惯）的问卷。通过国家芬兰癌症登记处确定癌症的发病情况。
结果
在平均 10.2 年的随访期间，诊断出 1703 例肺癌、799 例前列腺癌、365 例尿路上皮癌、316 例结直肠癌、224 例胃癌、192 例胰腺癌、184 例肾细胞癌和 175 例淋巴瘤。膳食丙烯酰胺摄入与肺癌风险呈正相关；多变量调整模型中，最高五分位与最低五分位的相对风险（RR）为 1.18（95%置信区间（CI）为 1.01-1.38，趋势检验 p 值为 0.11）。其他癌症与丙烯酰胺摄入无关。
结论
高丙烯酰胺摄入与男性吸烟者的肺癌风险增加有关，但与其他癌症无关。
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