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左氧氟沙星单独及与DnaK抑制剂联合使用对革兰氏阴性杆菌（包括耐左氧氟沙星菌株）的活性。

Activity of levofloxacin alone and in combination with a DnaK inhibitor against gram-negative rods, including levofloxacin-resistant strains.

作者信息

Credito Kim, Lin Gengrong, Koeth Laura, Sturgess Michael A, Appelbaum Peter C

机构信息

Department of Pathology, Hershey Medical Center, PA 17033, USA.

出版信息

Antimicrob Agents Chemother. 2009 Feb;53(2):814-7. doi: 10.1128/AAC.01132-08. Epub 2008 Nov 17.

DOI:10.1128/AAC.01132-08
PMID:19015359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2630640/
Abstract

Synergy time-kill testing of levofloxacin alone and in combination with CHP-105, a representative DnaK inhibitor, against 50 gram-negative rods demonstrated that 34 of the 50 strains tested showed significant synergy between levofloxacin and CHP-105 after 12 h and 24 h. Fourteen of these 34 organisms were quinolone resistant (levofloxacin MICs of > or =4 microg/ml).

摘要

单独使用左氧氟沙星以及将其与具有代表性的DnaK抑制剂CHP-105联合使用，对50株革兰氏阴性杆菌进行协同时间杀菌试验，结果显示，在12小时和24小时后，所测试的50株菌株中有34株在左氧氟沙星和CHP-105之间表现出显著协同作用。这34种微生物中有14种对喹诺酮耐药（左氧氟沙星最低抑菌浓度≥4微克/毫升）。

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