Warren M V, Studley M L, Dubus P, Fiette L, Rozell B, Quintanilla-Martinez L, Raspa M, Breuer M, Song J-Y, Gates H, Brown S D M, Schofield P N
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
J Pathol. 2009 Jan;217(1):4-13. doi: 10.1002/path.2460.
The generation of new mouse models of human disease is accelerating rapidly, due to the completion of whole-genome sequencing efforts and technological advances in the manipulation of the mouse genome. We sought to investigate manpower issues in the provision of histopathology expertise for mouse functional genomics and compared this to the perceived demand from principal investigators (PIs). Through the European Commission (EC)-funded PRIME pathology training initiative, two questionnaires were devised to collect information from pathologists and EC-funded PIs on the current provision of mouse histopathology expertise in Europe and the demands for this service. We find that pathological analysis is being performed almost exclusively by professionally qualified pathologists, generally employed in clinical diagnostic posts, where the work is undertaken as collaboration outside of their contractual commitments but without previous training in veterinary or comparative pathology. The results indicate that there is a lack of both trainees and provision of specialist training in this field. Unsurprisingly, the availability of diagnostic expertise and advice falls far short of the number of genetically engineered mice (GEM) being generated for analysis. We analyse these results with reference to previous studies and discuss solutions for the future recruitment, training and funding for pathologists in mouse functional genomics in Europe.
由于全基因组测序工作的完成以及小鼠基因组操作技术的进步，人类疾病新小鼠模型的生成正在迅速加速。我们试图调查为小鼠功能基因组学提供组织病理学专业知识方面的人力问题，并将其与主要研究者（PI）的预期需求进行比较。通过欧盟委员会（EC）资助的PRIME病理学培训计划，设计了两份问卷，以收集病理学家和由EC资助的PI关于欧洲目前小鼠组织病理学专业知识的提供情况以及对该服务的需求的信息。我们发现，病理分析几乎完全由具有专业资质的病理学家进行，这些病理学家通常受雇于临床诊断岗位，其工作是在合同承诺之外作为合作开展的，但之前没有接受过兽医或比较病理学方面的培训。结果表明，该领域既缺乏学员，也缺乏专业培训。不出所料，诊断专业知识和建议的可获得性远远低于为分析而生成的基因工程小鼠（GEM）的数量。我们参考之前的研究分析了这些结果，并讨论了欧洲未来在小鼠功能基因组学领域病理学家的招聘、培训和资金方面的解决方案。
