Sovari Ali A, Morita Norishige, Karagueuzian Hrayr S
Translational Arrhythmia Research Laboratory, Cardiovascular Research Laboratory, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
Redox Rep. 2008;13(6):242-5. doi: 10.1179/135100008X309000.
Oxidative stress in atrial tissue may be causally related to atrial fibrillation as suggested by clinical and animal studies. Reactive oxygen species (ROS) are known to play a key role in fibrosis and the induction of after-depolarization and triggered activity. Therefore, suppressing oxidative stress may have a potential beneficial role in the management of atrial fibrillation. Since increased NADPH oxidase activity is shown to play a key role in generation of ROS in atrial tissue and in atrial fibrillation, our proposed strategy to target upstream inhibition of ROS production by inhibition of NADPH oxidase activity may provide a novel approach to prevent atrial fibrillation recurrences. We hypothesize that apocynin could be effective against atrial fibrillation, by virtue of its potent inhibitory effect of a major oxidative system (i.e. NADPH oxidase) combined with its demonstrated anti-inflammatory, antifibrotic and antihypertensive effects which partially are driven from its antioxidant property. Atrial fibrillation is known to be initiated by the interaction of these multiple factors.
临床和动物研究表明，心房组织中的氧化应激可能与心房颤动存在因果关系。已知活性氧（ROS）在纤维化以及后去极化和触发活动的诱导中起关键作用。因此，抑制氧化应激可能在心房颤动的管理中具有潜在的有益作用。由于已表明增加的NADPH氧化酶活性在心房组织和心房颤动中ROS的产生中起关键作用，我们提出的通过抑制NADPH氧化酶活性来靶向上游抑制ROS产生的策略可能为预防心房颤动复发提供一种新方法。我们假设，apocynin可能对心房颤动有效，这是因为它对主要氧化系统（即NADPH氧化酶）具有强大的抑制作用，同时其已证明的抗炎、抗纤维化和抗高血压作用部分是由其抗氧化特性驱动的。已知心房颤动是由这些多种因素的相互作用引发的。
