Alwan W H, Carter S D, Bennett D, Edwards G B
Department of Veterinary Pathology, University of Liverpool, UK.
Equine Vet J. 1991 Jan;23(1):44-7. doi: 10.1111/j.2042-3306.1991.tb02712.x.
Horse articular cartilage glycosaminoglycans (GAGs) were measured in synovial fluids from 48 joints affected with osteoarthritis (OA), 22 normal joints, four joints with osteochondritis, three joints with traumatic arthritis and seven joints infected with bacteria. Serum and urine from individual horses were also examined for the presence of GAGs. High levels of GAGs were found in synovial fluids (SF) from horses with OA. In each case, the level was higher in the synovial fluid than in the serum or urine from the same horse. Horses with OA showed high GAG levels in SF, serum and urine compared to horses with normal and infected joints. High levels were also found in horses with osteochondritis and traumatic arthritis. Levels of synovial fluid GAG reflect cartilage destruction in arthritis and may be useful for monitoring disease progression in the equine species.
对48个患骨关节炎（OA）的关节、22个正常关节、4个患骨软骨炎的关节、3个患创伤性关节炎的关节以及7个细菌感染关节的滑液进行了马关节软骨糖胺聚糖（GAGs）测定。还对每匹马的血清和尿液进行了GAGs检测。患OA的马的滑液（SF）中发现了高水平的GAGs。在每种情况下，滑液中的水平都高于同一匹马的血清或尿液中的水平。与关节正常和感染的马相比，患OA的马的滑液、血清和尿液中GAG水平较高。在患骨软骨炎和创伤性关节炎的马中也发现了高水平的GAGs。滑液GAG水平反映了关节炎中的软骨破坏情况，可能有助于监测马类疾病的进展。
