Arican M, Carter S D, Bennett D, May C
Department of Veterinary Pathology, University of Liverpool.
Res Vet Sci. 1994 May;56(3):290-7. doi: 10.1016/0034-5288(94)90144-9.
Glycosaminoglycans (GAG) and keratan sulphate (KS) were measured in sera and synovial fluids from dogs with either osteoarthritis (OA) or rupture of the cranial cruciate ligament (CCL) and normal dogs. The dogs with OA had higher synovial fluid GAG levels (P < 0.002) and serum KS (P < 0.03) compared to the normal dogs. No significant differences in serum GAG were found in either group. In both OA and rupture of the CCL, GAG levels were increased in the synovial fluid from the affected joint compared with the clinically normal (inactive) contralateral joint. Neither GAG nor KS measurements correlated with serum and synovial fluid antibodies to collagen type II, synovial fluid white cell count or age of dog. It is unlikely that the measurement of these cartilage breakdown products is of value for diagnostic or prognostic use in canine arthropathies.
对患骨关节炎（OA）或颅交叉韧带（CCL）断裂的犬以及正常犬的血清和滑液进行了糖胺聚糖（GAG）和硫酸角质素（KS）检测。与正常犬相比，患OA的犬滑液中GAG水平更高（P < 0.002），血清KS水平更高（P < 0.03）。两组血清GAG均未发现显著差异。在OA和CCL断裂中，与临床正常（非活动）的对侧关节相比，患侧关节滑液中的GAG水平升高。GAG和KS检测结果均与血清及滑液中抗II型胶原抗体、滑液白细胞计数或犬龄无关。这些软骨降解产物的检测对于犬关节病的诊断或预后评估不太可能有价值。
