加替沙星与头孢哌酮及头孢哌酮-舒巴坦对铜绿假单胞菌耐药菌株的协同作用
Synergy of gatifloxacin with cefoperazone and cefoperazone-sulbactam against resistant strains of Pseudomonas aeruginosa.
作者信息
Sivagurunathan N, Krishnan S, Rao J Venkat, Nagappa Anantha Naik, Subrahmanyam V M, Vanathi B Meenashi
机构信息
Department of Pharmaceutical Biotechnology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, India.
Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India.
出版信息
J Med Microbiol. 2008 Dec;57(Pt 12):1514-1517. doi: 10.1099/jmm.0.2008/001636-0.
Chequerboard and time-kill methods were used to compare the in vitro efficacies of the combinations gatifloxacin (GAT) with cefoperazone (CFP) and GAT with cefoperazone-sulbactam (CFP-SUL) against 58 clinical isolates of Pseudomonas aeruginosa. The combinations GAT+CFP and GAT+CFP-SUL were shown to be synergistic for 36.2 and 58.6 % of isolates tested, respectively, using the chequerboard method. Time-kill studies with 11 strains showed synergy in 54.5 % for the GAT+CFP combination and 72.7 % for the GAT+CFP-SUL combination. The agreement between these two methods was found to be 72-81 %. There was a significant difference in synergy between the two combinations tested (P=0.011).
采用棋盘法和时间杀菌法比较加替沙星（GAT）与头孢哌酮（CFP）以及GAT与头孢哌酮-舒巴坦（CFP-SUL）联合用药对58株铜绿假单胞菌临床分离株的体外抗菌效果。使用棋盘法时，GAT+CFP和GAT+CFP-SUL联合用药分别对36.2%和58.6%的受试分离株显示协同作用。对11株菌株进行的时间杀菌研究表明，GAT+CFP联合用药的协同率为54.5%，GAT+CFP-SUL联合用药的协同率为72.7%。发现这两种方法的一致性为72%-81%。所测试的两种联合用药之间的协同作用存在显著差异（P=0.011）。
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