The human aldose reductase gene maps to chromosome region 7q35.
作者信息
Graham A, Heath P, Morten J E, Markham A F
机构信息
Biotechnology Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, UK.
出版信息
Hum Genet. 1991 Mar;86(5):509-14. doi: 10.1007/BF00194644.
PMID:1901827
Abstract
The human aldose reductase (AR) gene has been mapped to chromosome 7 using the polymerase chain reaction to specifically amplify the human AR sequence in hamster/human hybrid DNA and also in mouse/human monochromosome hybrids. The assignment to chromosome 7 was confirmed by in situ hybridisation to human metaphase chromosomes using a novel, rapid hybridisation, method giving a regional localisation at 7q35.
摘要
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