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人类NK-2受体基因定位于染色体区域10q11 - 21。

Human NK-2 receptor gene maps to chromosome region 10q11-21.

作者信息

Morten J E, Hopkins B, Powell S J, Graham A

机构信息

Biotechnology Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, UK.

出版信息

Hum Genet. 1991 Dec;88(2):200-3. doi: 10.1007/BF00206072.

DOI:10.1007/BF00206072
PMID:1661704
Abstract

The human NK-2 receptor gene has been mapped to chromosome 10 using the polymerase chain reaction to amplify specifically the human NK-2 receptor sequence in hamster/human hybrid DNA and also in mouse/human monochromosome hybrids. The assignment to chromosome 10 was confirmed by in situ hybridisation to human metaphase chromosomes, giving a regional localisation of 10q11-21.

摘要

利用聚合酶链反应特异性扩增仓鼠/人类杂交DNA以及小鼠/人类单染色体杂交体中的人类NK-2受体序列,已将人类NK-2受体基因定位于10号染色体。通过对人类中期染色体进行原位杂交,证实该基因定位于10号染色体,区域定位为10q11 - 21。

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本文引用的文献

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Genetic manipulation by means of microcell-mediated transfer of normal human chromosomes into recipient mouse cells.通过微细胞介导将正常人染色体转移到受体小鼠细胞中进行基因操作。
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Selective transfer of individual human chromosomes to recipient cells.
将人类个体染色体选择性转移至受体细胞。
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Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.用于镰状细胞贫血诊断的β-珠蛋白基因组序列的酶促扩增及限制性酶切位点分析。
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Introduction of human chromosome 11 via microcell transfer controls tumorigenic expression of HeLa cells.通过微细胞转移导入人类11号染色体可控制HeLa细胞的致瘤性表达。
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The gene for human complement component C9 mapped to chromosome 5 by polymerase chain reaction.通过聚合酶链反应将人类补体成分C9的基因定位到5号染色体上。
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Molecular characterization of rat substance K receptor and its mRNAs.大鼠P物质受体及其mRNA的分子特征
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Molecular characterization of a functional cDNA for rat substance P receptor.
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J Biol Chem. 1990 Nov 25;265(33):20455-62.