Naja Zoher, Al-Tannir Mohamad, El-Rajab Mariam, Ziade Fouad, Baraka Anis
Anesthesia and Pain Medicine Department, Makassed General Hospital, Beirut, Lebanon.
Pain Pract. 2009 Jan-Feb;9(1):51-8. doi: 10.1111/j.1533-2500.2008.00238.x. Epub 2008 Sep 9.
Postdural puncture headache (PDPH) is one of the most common complications of spinal anesthesia, where adequate hydration with bed rest in the horizontal position is the initial recommendation. Epidural blood patch is to date the most effective treatment, but it is an invasive procedure that may result in serious complications. The aim of the current study was to conduct a prospective, randomized, single-blinded comparison between bilateral occipital blockade and conventional expectant therapy in adults suffering from PDPH. A primary hypothesis was that occipital blockade would result in better pain management and quicker return to normal activity. Fifty adult patients diagnosed with PDPH were randomly divided into two equal groups of 25 each. All patients in the block group received greater and lesser occipital nerve blocks, whereas the control group received adequate hydration, complete bed rest, and analgesics. Forty-seven patients entered into the final analysis as three patients withdrew from study. Complete pain relief was achieved in 68.4% of block patients after 1 to 2 blocks, with 31.6% ultimately receiving up to 4 blocks. Visual analog scales were significantly lower in the block group (P < 0.01), and the block group consumed significantly less analgesics in the follow-up period (P < 0.05) compared with control group. Block patients had significantly shorter hospital stays and sick leave periods (P < 0.001). The studied method is superior to expectant conservative therapy in the treatment of patients suffering from PDPH.
硬膜穿刺后头痛(PDPH)是脊髓麻醉最常见的并发症之一,最初建议通过充分补液并平卧休息来缓解。硬膜外血贴是迄今为止最有效的治疗方法,但它是一种侵入性操作,可能会导致严重并发症。本研究的目的是对患有PDPH的成人患者进行双侧枕神经阻滞与传统保守治疗的前瞻性、随机、单盲比较。主要假设是枕神经阻滞能更好地控制疼痛并更快恢复正常活动。50例诊断为PDPH的成年患者被随机分为两组,每组25例。阻滞组的所有患者均接受了枕大神经和枕小神经阻滞,而对照组接受了充分补液、完全卧床休息和镇痛治疗。47例患者进入最终分析,3例退出研究。1至2次阻滞后,阻滞组68.4%的患者疼痛完全缓解,31.6%的患者最终接受了多达4次阻滞。与对照组相比,阻滞组的视觉模拟评分显著更低(P < 0.01),且随访期间阻滞组的镇痛药消耗量显著更少(P < 0.05)。阻滞组患者的住院时间和病假时间显著更短(P < 0.001)。在治疗PDPH患者方面,所研究的方法优于保守治疗。