Haricharan Ramanath N, Georgeson Keith E
Division of Pediatric Surgery, Department of General Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.
Semin Pediatr Surg. 2008 Nov;17(4):266-75. doi: 10.1053/j.sempedsurg.2008.07.005.
Hirschsprung disease is a relatively common condition managed by pediatric surgeons. Significant advances have been made in understanding its etiologies in the last decade, especially with the explosion of molecular genetic techniques and early diagnosis. The surgical management has progressed from a two- or three-stage procedure to a primary operation. More recently, definitive surgery for Hirschsprung disease through minimally invasive techniques has gained popularity. In neonates, the advancement of treatment strategies for Hirschsprung disease continues with reduced patient morbidity and improved outcomes.
先天性巨结肠症是一种由小儿外科医生治疗的相对常见的病症。在过去十年中，对其病因的理解取得了重大进展，尤其是随着分子遗传学技术的迅猛发展和早期诊断技术的进步。手术治疗已从两阶段或三阶段手术发展为一期手术。最近，通过微创技术进行先天性巨结肠症的确定性手术越来越受欢迎。在新生儿中，先天性巨结肠症的治疗策略不断进步，患者发病率降低，治疗效果得到改善。
