Peters Jan, Thoma Patrizia, Koch Benno, Schwarz Michael, Daum Irene
Department of Neuropsychology, Ruhr-University of Bochum, Germany.
Cortex. 2009 May;45(5):592-601. doi: 10.1016/j.cortex.2008.09.001. Epub 2008 Sep 25.
Damage to the left medial temporal lobe (MTL) leads to an impairment of verbal recognition memory, affecting both the process of conscious recollection and familiarity-based recognition. Neuroimaging evidence, on the other hand, suggests a bilateral MTL contribution to verbal recollection. We investigated verbal recognition memory in three patients with focal ischemic lesions to the right MTL. The dual-process signal detection model and the process-dissociation procedure were applied to assess the contributions of recollection and familiarity to recognition memory. Compared to a group of 27 healthy age-matched controls, patients were impaired at recollection while familiarity was intact, and this effect was found for both estimation procedures. Detailed single-case analyses confirmed this pattern in two of the three right MTL patients. The findings suggest that, when task demands are high, as during recollective recognition, the right anterior hippocampus may also contribute to verbal recollection, thereby confirming neuroimaging evidence of a joint involvement of the left and the right MTL in verbal recollection.
左侧内侧颞叶（MTL）受损会导致言语识别记忆受损，影响有意识回忆和基于熟悉度的识别过程。另一方面，神经影像学证据表明双侧MTL对言语回忆有贡献。我们研究了三名右侧MTL局灶性缺血性病变患者的言语识别记忆。应用双加工信号检测模型和加工分离程序来评估回忆和熟悉度对识别记忆的贡献。与27名年龄匹配的健康对照组相比，患者在回忆方面受损，而熟悉度完好，并且在两种评估程序中均发现了这种效应。详细的单病例分析在三名右侧MTL患者中的两名中证实了这一模式。研究结果表明，当任务要求较高时，如在回忆性识别过程中，右侧前海马体可能也有助于言语回忆，从而证实了神经影像学证据中关于左侧和右侧MTL共同参与言语回忆的观点。
