Merchant Thomas E, Li Chenghong, Xiong Xiaoping, Gaber M Waleed
Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.
Int J Radiat Oncol Biol Phys. 2009 May 1;74(1):159-67. doi: 10.1016/j.ijrobp.2008.07.058. Epub 2008 Nov 18.
To determine the time course and clinical significance of cytokines and peptide growth factors in pediatric patients with ependymoma treated with postoperative radiotherapy (RT).
We measured 15 cytokines and growth factors (fibroblast growth factor, epidermal growth factor, vascular endothelial growth factor [VEGF], interleukin [IL]-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, interferon-gamma, tumor necrosis factor-alpha, granulocyte-macrophage colony-stimulating factor, monocyte chemoattractant protein-1, and macrophage inflammatory protein-alpha) from 30 patients before RT and 2 and 24 h, weekly for 6 weeks, and at 3, 6, 9, and 12 months after the initiation of RT. Two longitudinal models for the trend of log-transformed measurements were fitted, one during treatment and one through 12 months.
During RT, log IL-8 declined at a rate of -0.10389/wk (p = 0.0068). The rate of decline was greater (p = 0.028) for patients with an infratentorial tumor location. The decline in IL-8 after RT was significant when stratified by infratentorial tumor location (p = 0.0345) and more than one surgical procedure (p = 0.0272). During RT, the decline in log VEGF was significant when stratified by the presence of a ventriculoperitoneal shunt. After RT, the log VEGF declined significantly at a rate of -0.06207/mo. The decline was significant for males (p = 0.0222), supratentorial tumors (p = 0.0158), one surgical procedure (p = 0.0222), no ventriculoperitoneal shunt (p = 0.0005), and the absence of treatment failure (p = 0.0028).
The pro-inflammatory cytokine IL-8 declined significantly during RT and the decline differed according to tumor location. The angiogenesis factor VEGF declined significantly during the 12 months after RT. The decline was greater in males, those without a ventriculoperitoneal shunt, and in those with favorable disease factors, including one surgical procedure, supratentorial tumor location, and tumor control.
确定接受术后放疗（RT）的小儿室管膜瘤患者体内细胞因子和肽生长因子的时间进程及临床意义。
我们检测了30例患者放疗前、放疗开始后2小时和24小时、每周1次共6周以及放疗开始后3个月、6个月、9个月和12个月时的15种细胞因子和生长因子（成纤维细胞生长因子、表皮生长因子、血管内皮生长因子[VEGF]、白细胞介素[IL]-1β、IL-2、IL-4、IL-5、IL-6、IL-8、IL-10、干扰素-γ、肿瘤坏死因子-α、粒细胞-巨噬细胞集落刺激因子、单核细胞趋化蛋白-1和巨噬细胞炎性蛋白-α）。对对数转换测量值的趋势拟合了两种纵向模型，一种用于治疗期间，另一种用于整个12个月期间。
放疗期间，对数IL-8以-0.10389/周的速率下降（p = 0.0068）。幕下肿瘤部位的患者下降速率更大（p = 0.028）。放疗后，按幕下肿瘤部位分层时IL-8的下降具有显著性（p = 0.0345），且手术次数超过一次时也具有显著性（p = 0.0272）。放疗期间，按是否存在脑室腹腔分流分层时，对数VEGF的下降具有显著性。放疗后，对数VEGF以-0.06207/月的速率显著下降。男性（p = 0.0222）、幕上肿瘤（p = 0.0158）、手术一次（p = 0.0222）、无脑室腹腔分流（p = 0.0005）以及无治疗失败（p = 0.0028）的患者下降具有显著性。
促炎细胞因子IL-8在放疗期间显著下降，且下降情况因肿瘤部位而异。血管生成因子VEGF在放疗后的12个月内显著下降。男性、无脑室腹腔分流者以及具有良好疾病因素（包括手术一次、幕上肿瘤部位和肿瘤得到控制）的患者下降幅度更大。
