Cavallo J-D, Mérens A
Service de biologie, hôpital d'instruction des armées Bégin, 69, avenue de Paris, 94163 Saint-Mandé cedex, France.
Pathol Biol (Paris). 2008 Nov-Dec;56(7-8):435-8. doi: 10.1016/j.patbio.2008.07.028. Epub 2008 Nov 18.
Breakpoints harmonization concerning six European committees is being conducted within the European Committee for Antimicrobial Susceptibility Testing for a few years and is now finalized for beta-lactam antibiotics. This article describes the impact of breakpoint modifications on percentage of susceptibility of P. aeruginosa to beta-lactams in comparison with previous French National Committee breakpoints (CA-SFM). This harmonization leads to the need for new recommendations about diameter breakpoints and for updating breakpoints in antibiotic susceptibility testing automated devices. Moreover, it points out the importance of MICs and quantitative diameter data in order to follow the evolution of antibiotic susceptibility.
欧洲抗菌药物敏感性试验委员会针对六个欧洲委员会的折点协调工作已经开展了数年，目前β-内酰胺类抗生素的协调工作已完成。本文描述了与之前法国国家委员会（CA-SFM）的折点相比，折点修改对铜绿假单胞菌对β-内酰胺类药物敏感性百分比的影响。这种协调导致需要关于直径折点的新建议，并更新抗生素敏感性检测自动化设备中的折点。此外，它指出了最低抑菌浓度（MIC）和定量直径数据对于跟踪抗生素敏感性演变的重要性。
