Nijhawan Sunita R, Banks Sarah J L, Aziz Tipu Z, Panourias Ioannis, Gregory Ralph, Yianni John, Parkin Simon, Joint Carole, Scott Richard B
Department of Clinical Neuropsychology, Russell-Cairns Unit, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, UK.
J Clin Neurosci. 2009 Jan;16(1):44-50. doi: 10.1016/j.jocn.2008.03.008. Epub 2008 Nov 18.
Cognitive functioning and health-related quality of life were assessed pre- and post-operatively in a consecutive series of 31 Parkinson's disease patients who underwent stereotactic unilateral thalamotomy (22 left-sided, 9 right-sided) for tremor alleviation. Neuropsychological functions assessed included verbal and visual memory, language and speech production, verbal and non-verbal reasoning, and attention and working memory. Health-related quality of life measures included both general and disease-specific questionnaires. We found a statistically significant post-operative decline in phonetic verbal fluency scores for left-operated patients, as well as improvements in self-ratings of stigma and bodily discomfort on the disease-specific quality of life questionnaire. These findings suggest that thalamotomy, when indicated, has limited cognitive sequelae and may result in improved quality of life in areas specific to Parkinson's disease.
对连续31例接受立体定向单侧丘脑切开术（左侧22例，右侧9例）以缓解震颤的帕金森病患者在术前和术后进行了认知功能和健康相关生活质量评估。评估的神经心理功能包括言语和视觉记忆、语言和言语表达、言语和非言语推理以及注意力和工作记忆。健康相关生活质量测量包括一般问卷和疾病特异性问卷。我们发现，接受左侧手术的患者术后语音言语流畅性得分有统计学意义的下降，以及在疾病特异性生活质量问卷上耻辱感和身体不适的自我评分有所改善。这些发现表明，丘脑切开术在有指征时，认知后遗症有限，并且可能会改善帕金森病特定领域的生活质量。
