巴西的伯基特淋巴瘤具有地理上不同的临床病理特征。
Burkitt lymphoma in Brazil is characterized by geographically distinct clinicopathologic features.
作者信息
Queiroga Eduardo M, Gualco Gabriela, Weiss Lawrence M, Dittmer Dirk P, Araujo Iguaracyra, Klumb Claudette E N, Harrington William J, Bacchi Carlos E
机构信息
Pathology Reference Laboratory, Botucatu, São Paulo, Brazil.
出版信息
Am J Clin Pathol. 2008 Dec;130(6):946-56. doi: 10.1309/AJCP64YOHAWLUMPK.
Burkitt lymphoma (BL) is a highly aggressive non-Hodgkin lymphoma with a consistent MYC translocation. Epstein-Barr virus (EBV) has been associated with BL at different frequencies, depending on the clinical variant and geographic regions. This is a large-scale study of BL in Brazil, including 234 patients from 5 geographic regions that are widely disparate socioeconomically, including pediatric (61.1%) and adult (37.6%) populations. EBV was present in 52.6% of all BL cases, varying from 29% (12/42) in the South to 76% (13/17) in the North. Most of the cases were EBV type A. The frequency was higher in the pediatric group, and EBV association within this age range predominated in all regions except the South. Expression of p53 protein was observed in 16.2%, and only rare cases showed p63 expression. BL in Brazil is regionally distinct and has a low incidence of p53 overexpression and a higher-than-expected association with EBV in sporadic cases.
伯基特淋巴瘤（BL）是一种具有一致MYC易位的高度侵袭性非霍奇金淋巴瘤。爱泼斯坦-巴尔病毒（EBV）与BL的关联频率不同，这取决于临床变异型和地理区域。这是一项对巴西BL的大规模研究，包括来自5个社会经济差异很大的地理区域的234名患者，其中包括儿童（61.1%）和成人（37.6%）人群。EBV存在于所有BL病例的52.6%中，从南部的29%（12/42）到北部的76%（13/17）不等。大多数病例为A型EBV。该频率在儿童组中更高，并且在除南部以外的所有地区，该年龄范围内的EBV关联均占主导。观察到16.2%的病例有p53蛋白表达，仅有罕见病例显示p63表达。巴西的BL在区域上具有独特性，p53过表达的发生率较低，且在散发病例中与EBV的关联高于预期。
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