Suarez Hamlet, Geisinger Dario, Suarez Alejo, Carrera Ximena, Buzo Ricardo, Amorin Ignacio
Laboratory of Otoneurology, CLAEH School of Medicine, British Hospital, Montevideo, Uruguay.
Acta Otolaryngol. 2009 Apr;129(4):354-60. doi: 10.1080/00016480802495446.
This study suggests that patients with Parkinson's disease (PD), even in the early stages, have decreased body limits of stability (LOS) and changes in the visual input impair their postural control.
To assess the LOS and the postural responses after changes in visual input in a group of PD patients in stage 1 of the Hoehn and Yahr classification.
Twenty PD patients in stage 1 and a group of 24 normal subjects as control were assessed in two tests: (1) the LOS and (2) measurement of the body center of pressure area (COP) 10 s before and after sudden change in visual flow velocity. We also investigated labeling of the COP trajectory in these two periods. The stimulation paradigm was a horizontal optokinetic stimulation (60 degrees /s and suddenly stopped) using a virtual reality system.
LOS showed significant decrease in PD patients as compared with the control group (p<0.001, Kruskal-Wallis and Wilcoxon ranked test). The COP values increased significantly (p<0.001, Wilcoxon signed rank test) after sudden changes in the visual flow velocity in relation to the control group. After the visual stop the PD patient showed a spatial 'roaming' approaching the limits of stability and therefore impairing the postural control.
本研究表明，帕金森病（PD）患者即使在早期阶段，其身体稳定极限（LOS）也会降低，视觉输入的变化会损害他们的姿势控制。
评估一组处于Hoehn和Yahr分类第1阶段的PD患者的LOS以及视觉输入变化后的姿势反应。
对20名第1阶段的PD患者和一组24名正常受试者作为对照进行两项测试：（1）LOS测试；（2）在视觉流速突然变化前后10秒测量身体压力中心面积（COP）。我们还研究了这两个时期COP轨迹的标记情况。刺激范式是使用虚拟现实系统进行水平视动刺激（60度/秒并突然停止）。
与对照组相比，PD患者的LOS显著降低（p<0.001，Kruskal-Wallis和Wilcoxon秩和检验）。与对照组相比，视觉流速突然变化后，PD患者的COP值显著增加（p<0.001，Wilcoxon符号秩和检验）。视觉停止后，PD患者表现出接近稳定极限的空间“漫游”，从而损害姿势控制。
