Yang Xinmai, Wang Lihong V
Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, St. Louis, Missouri 63130, USA.
J Biomed Opt. 2008 Jul-Aug;13(4):044009. doi: 10.1117/1.2967907.
Photoacoustic tomography (PAT) is applied to image the brain cortex of a monkey through the intact scalp and skull ex vivo. The reconstructed PAT image shows the major blood vessels on the monkey brain cortex. For comparison, the brain cortex is imaged without the scalp, and then imaged again without the scalp and skull. Ultrasound attenuation through the skull is also measured at various incidence angles. This study demonstrates that PAT of the brain cortex is capable of surviving the ultrasound signal attenuation and distortion caused by a relatively thick skull.
光声断层扫描（PAT）被用于在体外通过完整的头皮和颅骨对猴子的大脑皮层进行成像。重建后的PAT图像显示了猴子大脑皮层上的主要血管。为作比较，先在没有头皮的情况下对大脑皮层成像，然后再在没有头皮和颅骨的情况下成像。还在不同入射角下测量了超声透过颅骨的衰减情况。这项研究表明，大脑皮层的PAT能够经受住由相对较厚的颅骨引起的超声信号衰减和失真。
