光声断层扫描检测可卡因诱导的大鼠脑激活。
Detection of cocaine induced rat brain activation by photoacoustic tomography.
机构信息
KU Bioengineering Research Center, Department of Mechanical Engineering, The University of Kansas, 5109 Learned Hall, 1530 West 15th Street, Lawrence, KS 66045, USA.
出版信息
J Neurosci Methods. 2011 Feb 15;195(2):232-5. doi: 10.1016/j.jneumeth.2010.12.006. Epub 2010 Dec 14.
Abstract
Photoacoustic tomography (PAT) was used to detect the progressive changes on the cerebral cortex of Sprague-Dawley rats after the administration of cocaine hydrochloride. Different concentrations (0, 2.5, and 5.0 mg per kg body) of cocaine hydrochloride in saline solution were injected into Sprague-Dawley rats through tail veins. Cerebral cortex images of the animals were continuously acquired by PAT. For continuous observation, PAT system used multi-transducers to reduce the scanning time and maintain a good signal-to-noise ratio (SNR). The obtained photoacoustic images were compared with each other and confirmed that changes in blood volume were induced by cocaine hydrochloride injection. The results demonstrate that PAT may be used to detect the effects of drug abuse-induced brain activation.
摘要
光声断层扫描（PAT）用于检测盐酸可卡因给药后 Sprague-Dawley 大鼠大脑皮层的渐进性变化。将不同浓度（0、2.5 和 5.0mg/kg 体重）的盐酸可卡因溶于生理盐水后经尾静脉注入 Sprague-Dawley 大鼠体内。通过 PAT 连续获取动物的大脑皮层图像。为了进行连续观察，PAT 系统使用多换能器减少扫描时间并保持良好的信噪比（SNR）。比较获得的光声图像并证实盐酸可卡因注射可引起血容量变化。结果表明，PAT 可用于检测药物滥用引起的大脑激活的影响。
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