Na Shuai, Wang Lihong V
Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
Caltech Optical Imaging Laboratory, Department of Electrical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.
Biomed Opt Express. 2021 Jun 15;12(7):4056-4083. doi: 10.1364/BOE.423707. eCollection 2021 Jul 1.
The successes of magnetic resonance imaging and modern optical imaging of human brain function have stimulated the development of complementary modalities that offer molecular specificity, fine spatiotemporal resolution, and sufficient penetration simultaneously. By virtue of its rich optical contrast, acoustic resolution, and imaging depth far beyond the optical transport mean free path (∼1 mm in biological tissues), photoacoustic computed tomography (PACT) offers a promising complementary modality. In this article, PACT for functional human brain imaging is reviewed in its hardware, reconstruction algorithms, demonstration, and potential roadmap.
磁共振成像和现代人类脑功能光学成像的成功激发了互补成像模式的发展，这些模式能够同时提供分子特异性、精细的时空分辨率和足够的穿透深度。光声计算机断层扫描（PACT）凭借其丰富的光学对比度、声学分辨率以及远超光学传输平均自由程（生物组织中约为1毫米）的成像深度，提供了一种很有前景的互补成像模式。本文从硬件、重建算法、实例展示及潜在发展路线等方面对用于人类脑功能成像的PACT进行了综述。
