No Keun-Sik, Kwong Richard, Chou Pai H, Cerussi Albert
University of California, Irvine, Beackman Laser Institute Laser Medical and Microbeam Program, 1110 Health Sciences Road, East, Irvine, California 92612, USA.
J Biomed Opt. 2008 Sep-Oct;13(5):050509. doi: 10.1117/1.2998473.
A board-level broadband frequency domain photon migration (mini-FDPM) instrument has been constructed to replace a conventional network-analyzer-based FDPM instrument. The mini-FDPM instrument with four wavelengths (681, 783, 823, and 850 nm), matches conventional FDPM instrument in performance (-88 dBm noise level, 100 dB dynamic range) and bandwidth (1 GHz), and recovers the same optical properties within about 6% in absorption and 4% in reduced scattering for liquid phantoms covering a wide range of relevant optical properties. Compared to the conventional FDPM instrument, the mini-FDPM instrument is more than 5x faster (approximately 200 ms per 401 modulation frequencies) and several orders of magnitude less in size and cost. Standard fiber-optic-based probes can be used with the mini-FDPM instrument, which increases applications in a number of clinically relevant measurement scenarios. By drastically reducing size and cost, FDPM miniaturization lowers barriers to access and will help promote FDPM in clinical research problems. The mini-FDPM instrument forms the core of a modular broadband diffuse optical spectroscopy instrument that can be used for a variety of clinical problems in imaging and functional monitoring (i.e., breast/skin cancer, brain activation, and exercise physiology).
已构建了一种板级宽带频域光子迁移（mini - FDPM）仪器，以取代传统的基于网络分析仪的FDPM仪器。这款具有四个波长（681、783、823和850 nm）的mini - FDPM仪器，在性能（-88 dBm噪声水平、100 dB动态范围）和带宽（1 GHz）方面与传统FDPM仪器相当，并且对于涵盖广泛相关光学特性的液体模型，在吸收方面能恢复相同的光学特性，误差在约6%以内，在约化散射方面误差在4%以内。与传统FDPM仪器相比，mini - FDPM仪器速度快5倍以上（每401个调制频率约200毫秒），尺寸和成本降低了几个数量级。标准的基于光纤的探头可与mini - FDPM仪器配合使用，这增加了在许多临床相关测量场景中的应用。通过大幅减小尺寸和降低成本，FDPM小型化降低了使用门槛，并将有助于在临床研究问题中推广FDPM。mini - FDPM仪器构成了模块化宽带漫射光学光谱仪器的核心，可用于成像和功能监测中的各种临床问题（即乳腺癌/皮肤癌、脑激活和运动生理学）。
