University of Cambridge, Department of Physics, Cambridge, United Kingdom.
University of Cambridge, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, United Kingdom.
J Biomed Opt. 2024 Jun;29(6):060801. doi: 10.1117/1.JBO.29.6.060801. Epub 2024 Jun 11.
The estimation of tissue optical properties using diffuse optics has found a range of applications in disease detection, therapy monitoring, and general health care. Biomarkers derived from the estimated optical absorption and scattering coefficients can reflect the underlying progression of many biological processes in tissues.
Complex light-tissue interactions make it challenging to disentangle the absorption and scattering coefficients, so dedicated measurement systems are required. We aim to help readers understand the measurement principles and practical considerations needed when choosing between different estimation methods based on diffuse optics.
The estimation methods can be categorized as: steady state, time domain, time frequency domain (FD), spatial domain, and spatial FD. The experimental measurements are coupled with models of light-tissue interactions, which enable inverse solutions for the absorption and scattering coefficients from the measured tissue reflectance and/or transmittance.
The estimation of tissue optical properties has been applied to characterize a variety of and tissues, as well as tissue-mimicking phantoms. Choosing a specific estimation method for a certain application has to trade-off its advantages and limitations.
Optical absorption and scattering property estimation is an increasingly important and accessible approach for medical diagnosis and health monitoring.
利用漫射光学估算组织的光学特性在疾病检测、治疗监测和一般保健方面有广泛的应用。从估算的光吸收和散射系数中得出的生物标志物可以反映组织中许多生物过程的潜在进展。
复杂的光组织相互作用使得难以分离吸收和散射系数，因此需要专用的测量系统。我们的目标是帮助读者了解基于漫射光学的不同估计方法在选择时所需的测量原理和实际注意事项。
估算方法可以分为：稳态、时域、时频域（FD）、空间域和空间 FD。实验测量与光组织相互作用的模型相结合，从而能够从测量的组织反射率和/或透射率中对吸收和散射系数进行反演求解。
组织光学特性的估算已应用于各种组织和组织模拟体的特性描述。选择特定的估计方法用于特定的应用需要权衡其优点和局限性。
光吸收和散射特性的估计是一种越来越重要且易于使用的医学诊断和健康监测方法。
