Kataoka Hiroshi, Taoka Toshiaki, Ueno Satoshi
Department of Neurology, Nara Medical University, Kashihara, Nara, Japan.
J Neuroimaging. 2009 Jul;19(3):246-9. doi: 10.1111/j.1552-6569.2008.00315.x. Epub 2008 Oct 22.
Contrast-enhanced magnetic resonance imaging (MRI) with fluid-attenuated inversion recovery (contrast FLAIR) is particularly useful for the detection of meningeal lesions. However, whether contrast FLAIR is useful in multiple sclerosis (MS) remains uncertain. This study evaluated the usefulness of contrast FLAIR in MS.
We prospectively studied the clinical histories and brain MRI studies of 6 patients with clinically definite MS diagnosed according to the new McDonald criteria. Contrast FLAIR (repetition time [TR] 9,000 ms; echo time [TE] 120 ms; inversion time [TI] 2,200 ms; 5-mm slice thickness, with a 1-mm interslice gap) was obtained with the use of a bolus of gadolinium diethylenetriamine pentaacetic acid.
Three enhancing plaques located in the periventricular or juxtacortical areas showed higher intensity on contrast FLAIR than on other MR sequences. In contrast, 8 enhancing plaques in the deep white matter or infratentorial areas showed no increased signals on contrast FLAIR.
Our findings suggest that early contrast-enhanced imaging with FLAIR may be helpful for the further detection of MS plaques, particularly those located in periventricular and juxtacortical lesions.
对比增强磁共振成像（MRI）结合液体衰减反转恢复序列（对比FLAIR）对脑膜病变的检测特别有用。然而，对比FLAIR在多发性硬化症（MS）中是否有用仍不确定。本研究评估了对比FLAIR在MS中的有用性。
我们前瞻性地研究了6例根据新的麦克唐纳标准诊断为临床确诊MS患者的临床病史和脑部MRI检查。使用钆喷酸葡胺团注获得对比FLAIR（重复时间[TR]9000毫秒；回波时间[TE]120毫秒；反转时间[TI]2200毫秒；5毫米层厚，层间距1毫米）。
位于脑室周围或皮质下区域的3个强化斑块在对比FLAIR上的信号强度高于其他MR序列。相比之下，位于深部白质或幕下区域的8个强化斑块在对比FLAIR上未显示信号增加。
我们的研究结果表明，早期FLAIR对比增强成像可能有助于进一步检测MS斑块，特别是位于脑室周围和皮质下的病变。
