Yoshimura Junichi, Nishiyama Kenichi, Fukuda Masafumi, Watanabe Masaki, Igarashi Hironaka, Fujii Yukihiko
Department of Neurosurgery and Center for Integrated Human Brain Science, University of Niigata, Japan.
J Neuroimaging. 2009 Oct;19(4):385-7. doi: 10.1111/j.1552-6569.2008.00298.x.
We herein report a rare case of cerebellopontine angle (CPA) medulloblastoma originating in the brainstem that demonstrated a very unusual clinical presentation and radiological appearances. A 25-year-old female was admitted to our hospital with a right hearing disturbance and a right facial palsy. A small non-enhanced lesion having minimal mass effect in the right CPA was identified by using a 1.5-tesla-MR system, whose size remained almost unchanged a year. The 3-tesla MR images revealed that the precise region was in the right side of the tegmentum of the lower pons to the inferior cerebellar peduncle and the flocculus. MR spectroscopic images using a 3-tesla system revealed a high ratio of choline-to-N-acetylaspartate in the region of interest in comparison to the contra-lateral side. Craniotomy and biopsy were performed. The histopathological diagnosis was medulloblastoma. The patient received craniospinal irradiation and chemotherapy, and achieved complete remission by the time of the follow-up MR images. She is now doing well with a full recovery of the right facial palsy. MR spectroscopic imaging is considered to be quite useful for the management of this rare type of brainstem tumor.
我们在此报告一例罕见的起源于脑干的桥小脑角(CPA)髓母细胞瘤,其临床表现和影像学表现非常不寻常。一名25岁女性因右耳听力障碍和右侧面神经麻痹入院。使用1.5特斯拉磁共振成像系统在右侧CPA发现一个小的无强化病灶,对周围组织几乎没有占位效应,其大小在一年内几乎没有变化。3特斯拉磁共振图像显示,精确区域位于脑桥下部被盖至小脑下脚和绒球的右侧。使用3特斯拉系统的磁共振波谱图像显示,与对侧相比,感兴趣区域的胆碱与N-乙酰天门冬氨酸比值较高。进行了开颅手术和活检。组织病理学诊断为髓母细胞瘤。患者接受了全脑全脊髓放疗和化疗,在随访磁共振图像时实现了完全缓解。她现在恢复良好,右侧面神经麻痹完全恢复。磁共振波谱成像被认为对这种罕见类型的脑干肿瘤的治疗非常有用。