Pos Pok P-Rop, Haddouche Djamel, Mauras Michel, Kuhlmann Erika, Burle Joëlle, Salmon Thierry, Berland Emilie, Coiffait P-Emmanuel, Viala Alain
INPS, Laboratoire de Police Scientifique de Marseille, Section Toxicologie, 97, boulevard Camille Flammarion, BP30, 13245 Marseille, France.
J Anal Toxicol. 2008 Nov-Dec;32(9):782-6. doi: 10.1093/jat/32.9.782.
Concomitant heart and peripheral blood determinations were performed on 40 fatal cases involving nordiazepam (20 cases) and bromazepam (20 cases). The heart blood concentration for the two drugs (588 ng/mL for nordiazepam and 802 ng/mL for bromazepam) does not differ from the corresponding peripheral blood concentration (587 ng/mL for nordiazepam and 883 ng/mL for bromazepam). The mean ratios for the heart and peripheral blood concentrations were 0.95 for nordiazepam and 0.86 for bromazepam. No postmortem redistribution was observed for these two benzodiazepines. The authors thus suggest that corresponding heart blood can be proposed in the quantitative analysis of these drugs when peripheral blood is unavailable. The present study also shows the stability of the two drugs after a year of storage.
对40例涉及硝西泮（20例）和溴西泮（20例）的死亡病例进行了心脏和外周血同步检测。两种药物的心脏血药浓度（硝西泮为588纳克/毫升，溴西泮为802纳克/毫升）与相应的外周血浓度（硝西泮为587纳克/毫升，溴西泮为883纳克/毫升）无差异。硝西泮和溴西泮的心脏与外周血浓度平均比值分别为0.95和0.86。未观察到这两种苯二氮䓬类药物的死后再分布情况。因此，作者建议在外周血无法获取时，可采用相应的心脏血进行这些药物的定量分析。本研究还显示了这两种药物在储存一年后的稳定性。
