Khan K S, Rizvi J H, Qureshi R N, Mazhar R
Department of Obstetrics and Gynaecology, Faculty of Health Sciences, Aga Khan University, Karachi.
J Pak Med Assoc. 1991 Feb;41(2):31-3.
In order to determine the prevalence of glucose intolerance in pregnancy, 1267 consecutive women attending the antenatal clinic of the Aga Khan University Medical Centre were subjected to a 75 g glucose challenge followed 2 hr later by plasma glucose determination irrespective of gestation on the first antenatal visit. The test was repeated at 28-32 weeks of gestation if the patients had an abnormal initial screen at less than 28 weeks gestation and a normal glucose tolerance test on diagnostic follow-up and for those who had a risk factor for gestational diabetes and a normal initial screen at less than 28 weeks gestation. The glucose challenge test was abnormal (2 hr plasma glucose greater than 140 mg%) in 8.6% of the screened population. Follow-up oral glucose tolerance test on these patients revealed a prevalence of 3.2% of gestational diabetes and 1.9% of impaired glucose tolerance test based on the modified O'Sullivan criteria. Improvement in cost effectiveness of screening programmes was adjudged possible by avoiding glucose tolerance tests in patients with 2 hr plasma glucose value of greater than 170 mg% after a 75 g oral glucose challenge for screening.
为了确定妊娠期糖耐量异常的患病率，对阿迦汗大学医学中心产前诊所连续就诊的1267名妇女进行了75克葡萄糖耐量试验，首次产前检查时无论孕周大小，在口服葡萄糖2小时后测定血糖。如果患者在妊娠28周前初次筛查异常，而诊断性随访时葡萄糖耐量试验正常，以及那些有妊娠期糖尿病危险因素且在妊娠28周前初次筛查正常的患者，则在妊娠28 - 32周时重复该试验。在筛查人群中，8.6%的葡萄糖耐量试验结果异常（口服葡萄糖2小时后血糖大于140毫克%）。对这些患者进行的后续口服葡萄糖耐量试验显示，根据改良的奥沙利文标准，妊娠期糖尿病的患病率为3.2%，糖耐量受损的患病率为1.9%。通过对口服75克葡萄糖进行筛查时2小时血糖值大于170毫克%的患者不进行葡萄糖耐量试验，判定筛查方案的成本效益有可能得到改善。
