du Plessis Adré J
Department of Neurology, Children's Hospital Boston, Boston, MA 02115, USA.
Clin Perinatol. 2008 Dec;35(4):609-41, v. doi: 10.1016/j.clp.2008.07.010.
Cerebrovascular insults are a leading cause of brain injury in premature infants, contributing to the high prevalence of motor, cognitive, and behavioral deficits. Understanding the complex pathways linking circulatory immaturity to brain injury in premature infants remains incomplete. These mechanisms are significantly different from those causing injury in the mature brain. The gaps in knowledge of normal and disturbed cerebral vasoregulation need to be addressed. This article reviews current understanding of cerebral perfusion, in the sick premature infant in particular, and discusses challenges that lie ahead.
脑血管损伤是早产儿脑损伤的主要原因，导致运动、认知和行为缺陷的高发生率。目前对于将循环系统不成熟与早产儿脑损伤联系起来的复杂途径的理解仍不完整。这些机制与导致成熟脑损伤的机制有显著不同。正常和紊乱的脑血管调节方面的知识空白需要得到解决。本文综述了目前对脑灌注的理解，特别是患病早产儿的脑灌注，并讨论了未来面临的挑战。
