漆树酸对脂氧合酶和前列腺素内过氧化物合酶的抑制作用。

Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids.

作者信息

Grazzini R, Hesk D, Heininger E, Hildenbrandt G, Reddy C C, Cox-Foster D, Medford J, Craig R, Mumma R O

机构信息

Interdepartmental Graduate Program in Genetics, Pennsylvania State University, University Park 16802.

出版信息

Biochem Biophys Res Commun. 1991 Apr 30;176(2):775-80. doi: 10.1016/s0006-291x(05)80252-9.

DOI:10.1016/s0006-291x(05)80252-9

PMID:1902673

Abstract

C22:1 omega 5-anacardic acid was found to be a good inhibitor of both potato lipoxygenase and ovine prostaglandin endoperoxide synthase with approximate IC50's of 6 and 27 microM, respectively. Very similar inhibition was seen with the crude exudate, rich in omega 5-anacardic acids, from glandular trichomes of an arthropod-resistant strain of geranium, Pelargonium xhortorum. The saturated anacardic acid (C22:0 sat), abundant in the trichome exudate of susceptible strains, was nearly as inhibitory toward both prostaglandin endoperoxide synthase and lipoxygenase as the omega 5-unsaturated compound. However, the dimethyl derivative of C22:1 omega 5-anacardic acid was a poor inhibitor of prostaglandin endoperoxide synthase and caused only moderate (32%) inhibition of lipoxygenase even at 135 microM. The possible role of prostaglandin endoperoxide synthase and lipoxygenase inhibition in the enhanced pest resistance of geraniums which produce the omega 5-AnAs is discussed.

摘要

已发现C22:1 ω5-漆树酸是马铃薯脂氧合酶和绵羊前列腺素内过氧化物合酶的良好抑制剂，其IC50值分别约为6和27微摩尔。在富含ω5-漆树酸的粗提物中也观察到了非常相似的抑制作用，该粗提物来自抗节肢动物的天竺葵品种（Pelargonium xhortorum）的腺毛。在感病品种的毛状体渗出物中大量存在的饱和漆树酸（C22:0饱和），对前列腺素内过氧化物合酶和脂氧合酶的抑制作用几乎与ω5-不饱和化合物相同。然而，C22:1 ω5-漆树酸的二甲基衍生物是前列腺素内过氧化物合酶的弱抑制剂，即使在135微摩尔时对脂氧合酶也仅产生中等程度（32%）的抑制作用。本文讨论了前列腺素内过氧化物合酶和脂氧合酶抑制作用在产生ω5-漆树酸的天竺葵增强抗虫性中的可能作用。