Drut R
Department of Pathology, Hospital de Niños, La Plata, Argentina.
Diagn Cytopathol. 1991;7(1):57-9. doi: 10.1002/dc.2840070115.
Fine-needle aspiration cytology (FNAC) of enlarged cervical lymph nodes of a 9-yr-old boy complaining of progressive weight loss showed a combination of a necrotizing granulomatous process and pigmented histiocytes. The diagnosis of chronic granulomatous disease (CGD) of childhood was proposed, and it was later confirmed by histology. Although the NBT test was negative, the patient responded well to prolonged bactericidal therapy with trimethoprim-sulfamethoxazole associated with parenteral nutrition, indicating a rare case of CGD with a negative Nitro-Blue Tetrazolium (NBT) test. The cytologic findings appear to be unique for this disease.
一名9岁男孩因体重逐渐减轻前来就诊，对其肿大的颈部淋巴结进行细针穿刺细胞学检查（FNAC），结果显示为坏死性肉芽肿性病变与色素性组织细胞并存。初步诊断为儿童慢性肉芽肿病（CGD），后经组织学检查得以证实。尽管硝基四氮唑蓝（NBT）试验结果为阴性，但该患者对复方新诺明联合肠外营养的长期杀菌治疗反应良好，提示这是一例罕见的NBT试验阴性的CGD病例。该疾病的细胞学表现似乎具有独特性。
