Pettinato G, Manivel J C, d'Amore E S, Petrella G
Department of Pathology, 2nd Medical School, University of Naples, Italy.
Acta Cytol. 1990 Nov-Dec;34(6):771-7.
A fine needle aspiration (FNA) biopsy of an enlarged lymph node in a three-year-old boy who had asymptomatic cervical and submandibular lymphadenopathy showed large histiocytes with abundant pale, eosinophilic cytoplasm containing well-preserved lymphocytes and occasional plasma cells and granulocytes. These features were consistent with a diagnosis of sinus histiocytosis with massive lymphadenopathy (SHML). Immunophenotypic study of the histiocytes, performed on the FNA smears and on paraffin-embedded sections, showed reactivity for S-100 protein and alpha-1-antichymotrypsin and negativity for lysozyme. These features, which are characteristic of SHML, demonstrate the reliability of FNA cytology in making the diagnosis of this disorder.
对一名三岁男孩肿大淋巴结进行的细针穿刺活检（FNA）显示，该男孩有无症状的颈部和颌下淋巴结病，活检结果显示存在大量组织细胞，其细胞质丰富、淡染、嗜酸性，含有保存完好的淋巴细胞，偶尔还有浆细胞和粒细胞。这些特征符合巨大淋巴结病性窦组织细胞增生症（SHML）的诊断。在FNA涂片和石蜡包埋切片上对组织细胞进行的免疫表型研究显示，其对S-100蛋白和α-1抗糜蛋白酶呈阳性反应，对溶菌酶呈阴性反应。这些SHML的特征性表现证明了FNA细胞学在诊断该疾病方面的可靠性。
