Kaiser Vera B, Charlesworth Brian
Institute of Evolutionary Biology, School of Biological Sciences, The University of Edinburgh, Ashworth Laboratories, The King's Buildings, West Mains Road, Edinburgh EH9 3JT, UK.
Trends Genet. 2009 Jan;25(1):9-12. doi: 10.1016/j.tig.2008.10.009. Epub 2008 Nov 21.
Analyzing regions of the Drosophila genome that have low levels of genetic recombination helps us understand the prevalence of sexual reproduction. Here, we show that genetic variability in these regions can be explained by interference among strongly deleterious mutations and that selection becomes progressively less effective in influencing the behaviour of neighbouring sites as the number of closely linked sites on a chromosome increases.
分析果蝇基因组中遗传重组水平较低的区域，有助于我们了解有性生殖的普遍性。在此，我们表明，这些区域的遗传变异性可以通过强有害突变之间的干扰来解释，并且随着染色体上紧密连锁位点数量的增加，选择在影响相邻位点行为方面的效果逐渐降低。
