奥利万星对耐甲氧西林金黄色葡萄球菌和耐万古霉素肠球菌的超微结构影响
Ultrastructural effects of oritavancin on methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus.
作者信息
Belley Adam, Harris Robert, Beveridge Terry, Parr Tom, Moeck Gregory
机构信息
Targanta Therapeutics Inc., St. Laurent, Quebec, Canada.
出版信息
Antimicrob Agents Chemother. 2009 Feb;53(2):800-4. doi: 10.1128/AAC.00603-08. Epub 2008 Nov 24.
Abstract
The ultrastructural effects of the lipoglycopeptide oritavancin on methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) were examined by transmission electron microscopy. Oritavancin but not vancomycin induced aberrant septum formation and loss of staining of nascent septal cross walls in MRSA. Septal distortions were also observed in VRE exposed to oritavancin.
摘要
通过透射电子显微镜检查了脂糖肽奥利万星对耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素肠球菌（VRE）的超微结构影响。奥利万星而非万古霉素可诱导MRSA中异常隔膜形成以及新生隔膜横壁染色缺失。在暴露于奥利万星的VRE中也观察到隔膜扭曲。
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