Bässler K H
Physiologisch-chemisches Institut, Johannes-Gutenberg-Universität Mainz.
Infusionstherapie. 1991 Feb;18(1):5-10.
Present knowledge on the possible cause of the tryptophan-induced eosinophilia-myalgia syndrome is discussed on the basis of a literature survey. The initially favored hypothesis of metabolites of a deranged tryptophan metabolism in some persons as cause of the syndrome has no plausibility for several reasons discussed in this paper. In the meantime trace backs of implicated tryptophan lots have led to one manufacturer who has changed his production procedure. The implicated lots contain a variety of impurities detectable by HPLC. Whether these impurities are the immediate cause of the syndrome or just markers remains to be established. An animal model suitable to clarify this question has recently been developed. Taking all these measures to identify and eliminate suspicious lots, there is no reason to withhold live saving artificial nutrition with tryptophan-containing preparations.
在文献调研的基础上，讨论了关于色氨酸诱导的嗜酸性粒细胞增多性肌痛综合征可能病因的现有知识。最初备受青睐的假说，即某些人色氨酸代谢紊乱的代谢产物是该综合征的病因，由于本文讨论的几个原因而不太可信。与此同时，对涉事色氨酸批次的追溯已指向一家改变了生产工艺的制造商。涉事批次含有多种可通过高效液相色谱法检测到的杂质。这些杂质是该综合征的直接病因还是仅仅是标志物，仍有待确定。最近已开发出一种适合阐明这个问题的动物模型。采取所有这些措施来识别和消除可疑批次后，没有理由拒绝使用含色氨酸制剂的救命人工营养。
