McIntosh A M, Moorhead T W J, McKirdy J, Hall J, Sussmann J E D, Stanfield A C, Harris J M, Johnstone E C, Lawrie S M
Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh EH105HF, UK.
Acta Psychiatr Scand. 2009 Mar;119(3):192-8. doi: 10.1111/j.1600-0447.2008.01286.x. Epub 2008 Nov 17.
We sought to address whether dorsal or ventral prefrontal gyrification is abnormal in bipolar disorder and to determine its diagnostic specificity and cognitive associations.
Forty-two out-patients with bipolar disorder, 28 with schizophrenia and 37 controls underwent magnetic resonance imaging. All subjects also underwent IQ and executive assessments using tasks whose performance has been localized to the ventral or dorsal prefrontal cortex. Cortical folding was quantified using the gyrification index (GI) and related to the cognitive measures.
Patients with bipolar disorder showed reduced prefrontal gyrification compared with controls but did not differ from patients with schizophrenia. Neither ventral nor dorsal GI was preferentially affected in either disorder. Current IQ was positively and significantly correlated with GI.
Patients with bipolar disorder and patients with schizophrenia have reduced prefrontal gyrification affecting both ventral and dorsal subregions. These reductions were significantly associated with cognitive impairments occurring in both disorders.
我们试图探讨双相情感障碍患者的背侧或腹侧前额叶脑回形成是否异常，并确定其诊断特异性及与认知的关联。
42例双相情感障碍门诊患者、28例精神分裂症患者及37名对照者接受了磁共振成像检查。所有受试者还使用了其表现已定位到腹侧或背侧前额叶皮层的任务进行智商和执行功能评估。使用脑回形成指数（GI）对皮质折叠进行量化，并与认知测量结果相关联。
与对照者相比，双相情感障碍患者的前额叶脑回形成减少，但与精神分裂症患者无差异。在这两种疾病中，腹侧或背侧GI均未受到优先影响。当前智商与GI呈显著正相关。
双相情感障碍患者和精神分裂症患者的前额叶脑回形成减少，影响腹侧和背侧亚区域。这些减少与两种疾病中出现的认知障碍显著相关。
