Demiray Gökcen, Değirmencioğlu Serkan, Uğurlu Erhan, Yaren Arzu
Medical Oncology Department, Zafer Goksin Oncology Center, Denizli State Hospital, Denizli, Turkey.
Medical Oncology Department, Fahri Goksin Oncology Center, Pamukkale University Hospital, Denizli, Turkey.
Clin Med Insights Oncol. 2017 Feb 20;11:1179554917690144. doi: 10.1177/1179554917690144. eCollection 2017.
Cancer cachexia is one of the most frequent effects of malignancy, is often associated with poor prognosis, and may account for up to 20% of cancer deaths. The aim of our study was to evaluate the relationship of cancer cachexia and serum levels of resistin and leptin in patients with advanced non-small cell lung cancer.
A total of 67 chemotherapy-naïve patients with advanced-stage non-small cell cancer and a control group containing 20 healthy individuals without a known chronic disease were enrolled in this study. All individuals in the control group were age and sex matched. Demographic, anthropometric, laboratory data and serum levels of adipokines were measured for 2 groups. Progression-free survival and overall survival were estimated using the Kaplan-Meier method. Survival among various factors was calculated using the log-rank test.
Patients presented significantly higher serum resistin ( = .0001) and lower serum leptin levels ( = .025) than the control group. Lower serum levels of leptin were correlated with overall survival ( = .011).
Serum leptin and resistin levels play key role as proinflammatory cytokines in lung cancer and cancer cachexia; however, their use as diagnostic or prognostic markers is not possible yet, and further large-scale studies are required to confirm our findings.
癌症恶病质是恶性肿瘤最常见的后果之一，常与预后不良相关，可能占癌症死亡人数的20%。我们研究的目的是评估晚期非小细胞肺癌患者中癌症恶病质与抵抗素和瘦素血清水平之间的关系。
本研究纳入了67例未经化疗的晚期非小细胞癌患者以及一个包含20名无已知慢性病的健康个体的对照组。对照组的所有个体在年龄和性别上相匹配。测量了两组的人口统计学、人体测量学、实验室数据以及脂肪因子的血清水平。使用Kaplan-Meier方法估计无进展生存期和总生存期。使用对数秩检验计算各种因素之间的生存率。
患者的血清抵抗素水平显著高于对照组（P = .0001），血清瘦素水平低于对照组（P = .025）。较低的血清瘦素水平与总生存期相关（P = .011）。
血清瘦素和抵抗素水平作为促炎细胞因子在肺癌和癌症恶病质中起关键作用；然而，目前它们还不能用作诊断或预后标志物，需要进一步的大规模研究来证实我们的发现。
