Lee Woo Jin, Lee Deok Woo, Chang Sung Eun, Lee Mi Woo, Choi Jee Ho, Moon Kee Chan, Koh Jai Kyoung
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Am J Dermatopathol. 2008 Dec;30(6):629-31. doi: 10.1097/DAD.0b013e3181812751.
Cutaneous metastases have been reported in 5%-10% of patients with internal malignancy. The most common clinical features are the sudden appearance of discrete, firm, and nontender nodules in a particular area of the body. The most frequent metastatic site of extraskeletal osteosarcoma (ESOS) is the lungs. Cutaneous metastasis of ESOS is rare. To our knowledge, only one case of ESOS has been reported with skin metastasis, histopathologically classified as the osteoblastic subtype. Here, we describe a case of chondroblastic ESOS arising in the mediastinum with metastasis to the skin. Our patient presented with a scalp nodule after diagnosis of primary ESOS at the mediastinum.
据报道，5%-10%的体内恶性肿瘤患者会发生皮肤转移。最常见的临床特征是在身体特定部位突然出现离散、坚硬且无压痛的结节。骨外骨肉瘤（ESOS）最常见的转移部位是肺部。ESOS的皮肤转移很少见。据我们所知，仅有一例ESOS皮肤转移的病例报道，组织病理学分类为成骨细胞亚型。在此，我们描述一例发生于纵隔的软骨母细胞型ESOS并伴有皮肤转移的病例。我们的患者在纵隔原发性ESOS诊断后出现头皮结节。
