Suh Jesse J, Pettinati Helen M, Kampman Kyle M, O'Brien Charles P
Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. Suh
Am J Addict. 2008 Nov-Dec;17(6):463-8. doi: 10.1080/10550490802409074.
Recently, we reported that naltrexone at 150 mg/day significantly decreased cocaine and alcohol use for men but not women with co-occurring cocaine and alcohol dependence. The present study is an exploratory investigation of predictors that explain the different gender responses to naltrexone, with a particular focus on differential predictors of treatment attrition. No significant predictors were associated with treatment discontinuation in men. Women, however, were more likely to discontinue treatment when reporting severe pre-treatment psychiatric problems or nausea while in treatment. Further research on the impact of pre-treatment and in-treatment gender differences with naltrexone is warranted.
最近，我们报告称，对于同时患有可卡因和酒精依赖的男性，每天服用150毫克纳曲酮可显著减少其可卡因和酒精的使用，但对女性则无此效果。本研究是一项探索性调查，旨在探究能够解释纳曲酮对不同性别产生不同反应的预测因素，特别关注治疗中断的差异预测因素。在男性中，没有显著的预测因素与治疗中断相关。然而，女性在报告有严重的治疗前精神问题或治疗期间出现恶心时，更有可能中断治疗。有必要进一步研究治疗前和治疗期间性别差异对纳曲酮疗效的影响。
