John William S, Wu Li-Tzy
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA; Department of Medicine, Division of General Internal Medicine, Duke University Medical Center, Durham, NC, USA; Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA; Center for Child and Family Policy, Sanford School of Public Policy, Duke University, Durham, NC, USA.
Drug Alcohol Depend. 2017 Nov 1;180:376-384. doi: 10.1016/j.drugalcdep.2017.08.031. Epub 2017 Sep 18.
Recent epidemiological data suggest a resurgence in cocaine use (CU) and cocaine-related problems in the United States. Demographic trends and correlates of problem CU are needed to determine potential factors that may be influencing the increased trend and to inform targeted prevention and intervention strategies.
Trends in any past-year CU, weekly CU, and cocaine use disorder (CUD) were examined among persons aged ≥12 years using the National Survey on Drug Use and Health from 2011 to 2015. Logistic regression analyses were used to determine correlates of past-year and weekly CU and CUD among adolescents and adults.
The prevalence of past-year CU from 2011 to 2015 increased among females, ages 18-25, ages ≥50, non-Hispanic Blacks, and persons reporting low income, past-year tobacco use, past-year alcohol use, and past-month binge and heavy alcohol use. The prevalence of weekly CU increased among persons aged ≥50 years and persons reporting past-month heavy alcohol use. A significant increase in the prevalence of CUD was only found among persons aged ≥50 years. Adjusted logistic regression showed that older age, large metropolitan residence, past-year tobacco, alcohol, cannabis, and heroin use, and major depressive episode were associated with increased odds of CU or CUD among both adolescents and adults; however, sex and race/ethnicity correlates differed among adolescents and adults.
Findings have implications for increased monitoring of CU-related indicators among some high-risk groups, such as females, older adults, Blacks, and polysubstance users. Targeted screening and intervention strategies among these population subgroups may be needed.
近期流行病学数据显示,美国可卡因使用(CU)及与可卡因相关问题呈再度流行之势。需要了解问题性可卡因使用的人口统计学趋势及其相关因素,以确定可能影响这一增长趋势的潜在因素,并为有针对性的预防和干预策略提供依据。
利用2011年至2015年的全国药物使用和健康调查,对年龄≥12岁人群过去一年的任何可卡因使用、每周可卡因使用及可卡因使用障碍(CUD)的趋势进行了研究。采用逻辑回归分析确定青少年和成年人过去一年及每周可卡因使用和可卡因使用障碍的相关因素。
2011年至2015年期间,过去一年可卡因使用的患病率在18 - 25岁女性、50岁及以上人群、非西班牙裔黑人以及报告低收入、过去一年吸烟、过去一年饮酒、过去一个月暴饮和大量饮酒的人群中有所上升。每周可卡因使用的患病率在50岁及以上人群以及报告过去一个月大量饮酒的人群中有所上升。仅在50岁及以上人群中发现可卡因使用障碍的患病率显著增加。调整后的逻辑回归显示,年龄较大、居住在大城市、过去一年使用烟草、酒精、大麻和海洛因以及患有重度抑郁发作与青少年和成年人中可卡因使用或可卡因使用障碍的几率增加相关;然而,青少年和成年人中性别和种族/族裔相关因素有所不同。
研究结果表明需要加强对一些高危人群(如女性、老年人、黑人及多药使用者)中与可卡因使用相关指标的监测。可能需要针对这些人群亚组采取有针对性的筛查和干预策略。