Larenza M P, Althaus H, Conrot A, Balmer C, Schatzmann U, Bettschart-Wolfensberger R
Anaesthesiology Section, Department of Clinical Veterinary Medicine, University of Bern, Switzerland.
Schweiz Arch Tierheilkd. 2008 Dec;150(12):599-607. doi: 10.1024/0036-7281.150.12.599.
Postoperative anaesthesia recovery and analgesia qualities were compared in cats anaesthetised with racemic ketamine (RS-ket) or S-ketamine (S-ket) undergoing orchiectomy. Twenty client-owned male cats received medetomidine (0.03 mg/kg) and S-ket (6 mg/kg; n = 10) or RS-ket (10 mg/kg; n = 10), all intramuscularly. After routine orchiectomy, animals received atipamezole (0.15 mg/kg) intramuscularly. Thirty and 60 min after atipamezole administration, one observer unaware of the treatment identity evaluated analgesia using a visual analogue scale (VAS) and, by means of four points scales, sedation, unprovoked behaviour and behavioural reactions to external stimuli. Cats with a VAS > or = 15 mm were to receive butorphanol. Times to sternal and standing positions were recorded. After 60 min, cats were given carprofen (4 mg/kg) subcutaneously. Anaesthesia with S-ket, at 60% of the RS-ket dose, provided faster recoveries. At 60 min, undisturbed cats in S-ket group had a trend towards fewer behavioural changes. Cats in RS-ket group were more sedate at 30 min and responded with a lower intensity to external stimulation. Immediate postoperative analgesia was considered adequate for both groups and no cat required butorphanol administration.
比较了接受睾丸切除术的猫在使用消旋氯胺酮（RS-氯胺酮）或S-氯胺酮（S-氯胺酮）麻醉后的术后麻醉恢复情况和镇痛质量。20只客户拥有的雄性猫肌肉注射美托咪定（0.03mg/kg）和S-氯胺酮（6mg/kg；n = 10）或RS-氯胺酮（10mg/kg；n = 10）。常规睾丸切除术后，动物肌肉注射阿替美唑（0.15mg/kg）。在给予阿替美唑后30分钟和60分钟，一名不知道治疗分组的观察者使用视觉模拟评分法（VAS）评估镇痛效果，并通过四点量表评估镇静、自发行为和对外界刺激的行为反应。VAS≥15mm的猫将接受布托啡诺治疗。记录达到胸骨卧位和站立位的时间。60分钟后，给猫皮下注射卡洛芬（4mg/kg）。S-氯胺酮以RS-氯胺酮剂量的60%进行麻醉时，恢复更快。在60分钟时，S-氯胺酮组未受干扰的猫行为变化有减少的趋势。RS-氯胺酮组的猫在30分钟时更镇静，对外界刺激的反应强度更低。两组术后即刻镇痛均被认为足够，没有猫需要给予布托啡诺治疗。
