Small Animal Teaching Hospital, Leahurst, Neston, UK.
RSPCA Greater Manchester Animal Hospital, Salford, UK.
J Feline Med Surg. 2020 Jun;22(6):589-597. doi: 10.1177/1098612X19868547. Epub 2019 Aug 16.
The aim of this study was to establish the optimum dosage and timing of administration of atipamezole in cats undergoing general anaesthesia incorporating ketamine to provide the shortest recovery possible without unacceptably compromising recovery quality.
In total, 128 healthy male cats (age range 2-108 months, weight range 0.56-5.22 kg) admitted for castration were randomly allocated to groups of 32. Anaesthesia was induced with 60 mg/m ketamine, 180 µg/m buprenorphine, 3 mg/m midazolam and 600 µg/m medetomidine intramuscularly (IM). Cats received 600 µg/m (groups 1ATI20 and 1ATI40) or 1.5 mg/m (groups 2.5ATI20 and 2.5ATI40) atipamezole IM either 20 (groups 1ATI20 and 2.5ATI20) or 40 mins (groups 1ATI40 and 2.5ATI40) after the 'quad'. Preparation time, surgical time, auricular temperature, times to sternal recumbency and first standing, and recovery quality score were recorded. Data were analysed using ANOVA, Kruskal-Wallis, Mann-Whitney U-tests and χ tests. Statistical significance was deemed to be ⩽0.05.
Groups did not differ significantly in preparation or surgical time. Auricular temperature decreased significantly over time ( <0.01) but did not differ between atipamezole treatment groups. Time to sternal recumbency in group 2.5ATI20 (52.9 ± 22.3 mins) was faster than group 1ATI20 (65.7 ± 24.7 mins) ( ⩽0.05), but there were no significant differences between other groups. Time to first standing and recovery quality scores did not differ significantly between groups. Minimal adverse effects were seen.
Atipamezole administration after 20 mins did not reduce recovery time but neither was recovery quality adversely affected compared with when it was administered after 40 mins, following datasheet recommendations with concurrent ketamine administration. The results of this study also suggest that an atipamezole:medetomidine dose ratio of 2.5:1 is more effective than 1:1 in reducing recovery time, regardless of timing of administration, although this only reached statistical significance for time to sternal recumbency when atipamezole was administered after 20 mins.
本研究旨在确定在接受包含氯胺酮的全身麻醉的猫中使用阿替美唑的最佳剂量和时间，以便在不影响恢复质量的情况下尽可能缩短恢复时间。
总共 128 只健康雄性猫（年龄范围 2-108 个月，体重范围 0.56-5.22kg）因去势而入院，随机分为 32 组。麻醉诱导采用 60mg/m 氯胺酮、180μg/m 布比卡因、3mg/m 咪达唑仑和 600μg/m 右美托咪定肌内注射（IM）。猫接受 600μg/m（1ATI20 和 1ATI40 组）或 1.5mg/m（2.5ATI20 和 2.5ATI40 组）阿替美唑 IM，分别在“四头肌”后 20 分钟（1ATI20 和 2.5ATI20 组）或 40 分钟（1ATI40 和 2.5ATI40 组）。记录准备时间、手术时间、耳温、胸骨卧位和第一次站立时间以及恢复质量评分。使用方差分析、克鲁斯卡尔-沃利斯检验、曼-惠特尼 U 检验和 χ 检验进行数据分析。认为统计学意义为 ⩽0.05。
各组在准备或手术时间上无显著差异。耳温随时间显著下降（ ⩽0.01），但在阿替美唑治疗组之间无差异。组 2.5ATI20（52.9±22.3 分钟）的胸骨卧位时间快于组 1ATI20（65.7±24.7 分钟）（ ⩽0.05），但其他组之间无显著差异。第一次站立时间和恢复质量评分在组间无显著差异。未见明显不良反应。
在与氯胺酮同时给药的情况下，按照数据表的建议，在 40 分钟后给药，而不是在 20 分钟后给药，虽然这仅在 20 分钟后给予阿替美唑时对胸骨卧位时间有统计学意义，但这并没有降低恢复质量。本研究的结果还表明，阿替美唑：右美托咪定剂量比为 2.5:1 比 1:1 更有效缩短恢复时间，无论给药时间如何，尽管这仅在 20 分钟后给予阿替美唑时对胸骨卧位时间有统计学意义。
