Testa Bernard, Krämer Stefanie D
Department of Pharmacy, University Hospital Centre (CHUV), Rue du Bugnon, CH-1011 Lausanne.
Chem Biodivers. 2008 Nov;5(11):2171-336. doi: 10.1002/cbdv.200890199.
This review continues a general presentation of the metabolism of drugs and other xenobiotics begun in three recent issues of Chemistry & Biodiversity. The present Part is dedicated to reactions of conjugation, namely methylation, sulfonation, and phosphorylation, glucuronidation and other glycosidations, acetylation and other acylations, the formation and fate of coenzyme A conjugates, glutathione conjugation, and the reaction of amines with carbonyl compounds. It presents the many transferases involved, their nomenclature, relevant biochemical properties, catalytic mechanisms, and the reactions they catalyze. Nonenzymatic reactions, mainly of glutathione conjugation, also receive due attention. A number of medicinally, environmentally, and toxicologically relevant examples are presented and discussed.
本综述延续了在最近三期《化学与生物多样性》中开始的关于药物和其他外源性物质代谢的总体介绍。本部分致力于结合反应，即甲基化、磺化和磷酸化、葡萄糖醛酸化和其他糖基化、乙酰化和其他酰化、辅酶A缀合物的形成和命运、谷胱甘肽结合以及胺与羰基化合物的反应。它介绍了所涉及的多种转移酶、它们的命名、相关生化特性、催化机制以及它们催化的反应。非酶反应，主要是谷胱甘肽结合反应，也得到了应有的关注。文中给出并讨论了一些与医学、环境和毒理学相关的例子。
